Evidence map›Paper›PMID 32015045›Full record

ArticleAntimicrobial agents and chemotherapy2020

Case Report of Increased Exposure to Antiretrovirals following Sleeve Gastrectomy.

Sarah Israel, Hila Elinav, Ram Elazary, Daniel Porat, Roni Gibori, Arik Dahan, Carmil Azran, Ehud Horwitz

Open access · greenAbstract readCase Reports
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
3.0field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 19 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Sarah Israel *Department of Internal Medicine, Mt. Scopus Hospital, Hebrew University Hadassah Medical Center, Jerusalem, Israel SarahI@hadassah.org.il.
Hila Elinav *Hadassah AIDS Center, Department of Clinical Microbiology and Infectious Diseases, Hebrew University Hadassah Medical Center, Jerusalem, Israel.
Ram ElazaryDepartment of Surgery, Hebrew University Hadassah Medical Center, Jerusalem, Israel.
Daniel PoratDepartment of Clinical Pharmacology, School of Pharmacy, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer Sheva, Israel.
Roni GiboriDepartment of Clinical Pharmacology, School of Pharmacy, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer Sheva, Israel.
Arik DahanDepartment of Clinical Pharmacology, School of Pharmacy, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer Sheva, Israel.
Carmil AzranClinical Pharmacy Unit, Herzliya Medical Center, Herzliya, Israel.
Ehud HorwitzHadassah AIDS Center, Department of Clinical Microbiology and Infectious Diseases, Hebrew University Hadassah Medical Center, Jerusalem, Israel.ORCID 0000-0003-2492-952X
Hadassah Medical Center · ILBen-Gurion University of the Negev · ILHerzliya Medical Center · IL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Bariatric surgery is increasingly performed in morbidly obese HIV patients. Limited data exist regarding antiretroviral drug exposure after bariatric surgery. We report a case of a morbidly obese HIV patient who underwent sleeve gastrectomy. Abacavir, lamivudine, and dolutegravir therapeutic drug monitoring was performed at several time points pre- and postsurgery. Significantly increased levels were measured, particularly for abacavir, whose levels increased ∼12-fold. Several mechanistic explanations for these findings are discussed.

Indexed as

Bariatric SurgeryGastrectomyAbacavirAdultAnti-Retroviral AgentsDideoxynucleosidesDolutegravirDrug MonitoringHeterocyclic Compounds, 3-RingHIV InfectionsHumansLamivudineMaleObesity, MorbidOxazinesPiperazinesAbacavirAnti-Retroviral AgentsDideoxynucleosidesDolutegravirHeterocyclic Compounds, 3-RingLamivudineOxazinesPiperazinesPyridonesantiretroviralsbariatric surgeryobesitysleeve gastrectomy

Identifiers

PMID32015045
PMCPMC7179309
OpenAlexW3003311153

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.