Evidence map›Paper›PMID 32015023›Full record

ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2020

Response Dissociation in Hierarchical Cortical Circuits: a Unique Feature of Autism Spectrum Disorder.

Tamar Kolodny, Michael-Paul Schallmo, Jennifer Gerdts, Raphael A Bernier, Scott O Murray

Open access · bronzeAbstract read
In one paragraph

Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.5field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 20 citations in OpenAlex.

  1. Multiscale Heterogeneity of White Matter Morphometry in Psychiatric Disorders.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2026
    Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Visual illusion susceptibility in autism: A neural model.The European journal of neuroscience · 2022
    Article
  8. Review
  9. Concentrations of Cortical GABA and Glutamate in Young Adults With Autism Spectrum Disorder.Autism research : official journal of the International Society for Autism Research · 2020
    Article
  10. Weaker neural suppression in autism.Nature communications · 2020
    Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Tamar KolodnyDepartments of Psychology, tamark@uw.edu.ORCID 0000-0002-0163-1766
Michael-Paul SchallmoDepartments of Psychology.ORCID 0000-0001-8252-8607
Jennifer GerdtsPsychiatry and Behavioral Sciences, University of Washington, Seattle, Washington 95195, and.
Raphael A BernierPsychiatry and Behavioral Sciences, University of Washington, Seattle, Washington 95195, and.ORCID 0000-0003-1854-2804
Scott O MurrayDepartments of Psychology.ORCID 0000-0003-3241-3646
University of Washington · USBenchmark Research (United States) · USUniversity of Minnesota · US

Funding

Mechanisms of Brain Dysmorphology in MN1 C-Terminal Truncation Syndrome, a Novel Intellectual Developmental Disability Disorder P50HD103524 · NICHD · UNIVERSITY OF WASHINGTON · PI Sandra E Juul · 2020 to 2026
$9.9M
Inhibitory dysfunction in autismR01MH106520 · NIMH · UNIVERSITY OF WASHINGTON · PI MURRAY, SCOTT O · 2015 to 2019
$2.7M
NIMH NIH HHS R01 MH106520
6 · The paper itself

Abstract

A prominent hypothesis regarding the pathophysiology of autism is that an increase in the balance between neural excitation and inhibition results in an increase in neural responses. However, previous reports of population-level response magnitude in individuals with autism have been inconsistent. Critically, network interactions have not been considered in previous neuroimaging studies of excitation and inhibition imbalance in autism. In particular, a defining characteristic of cortical organization is its hierarchical and interactive structure; sensory and cognitive systems are comprised of networks where later stages inherit and build upon the processing of earlier input stages, and also influence and shape earlier stages by top-down modulation. Here we used the well established connections of the human visual system to examine response magnitudes in a higher-order motion processing region [middle temporal area (MT+)] and its primary input region (V1). Simple visual stimuli were presented to adult individuals with autism spectrum disorders (ASD;

Indexed as

AdultAutism Spectrum DisorderBrain MappingEye MovementsFemaleHead MovementsHumansMagnetic Resonance ImagingMaleMotion PerceptionNerve NetNeural InhibitionPhotic StimulationPsychomotor PerformanceTemporal LobeYoung AdultautismE/I balancefMRIvisual cortex

Identifiers

PMID32015023
PMCPMC7083290
OpenAlexW3004177561

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.