Evidence map›Paper›PMID 32014896›Full record

ArticleInfection and immunity2020

Activation of ASC Inflammasome Driven by Toll-Like Receptor 4 Contributes to Host Immunity against Rickettsial Infection.

Claire Rumfield, Ilirjana Hyseni, Jere W McBride, David H Walker, Rong Fang

Open access · greenAbstract read
In one paragraph

Article in Infection and immunity, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
2.8field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 23 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Infection and immunity · 2025
    Article
  7. Article
  8. IL-1 Superfamily Member (Biomolecules · 2022
    Article
  9. Review
  10. Infection and immunity · 2022
    Review
  11. Article
  12. Review
  13. Article
  14. Subversion of Host Innate Immunity byFrontiers in immunology · 2021
    Article
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Claire RumfieldDepartment of Pathology, University of Texas Medical Branch, Galveston, Texas, USA.
Ilirjana HyseniDepartment of Pathology, University of Texas Medical Branch, Galveston, Texas, USA.
Jere W McBrideDepartment of Pathology, University of Texas Medical Branch, Galveston, Texas, USA.ORCID 0000-0003-3335-1539
David H WalkerDepartment of Pathology, University of Texas Medical Branch, Galveston, Texas, USA.
Rong FangDepartment of Pathology, University of Texas Medical Branch, Galveston, Texas, USA rofang@utmb.edu.ORCID 0000-0003-0213-0960
The University of Texas Medical Branch at Galveston · US

Funding

Biodefense Training ProgramT32AI060549 · NIAID · UNIVERSITY OF TEXAS MEDICAL BR GALVESTON · PI ASHOK K CHOPRA, Janice J Endsley · 2004 to 2026
$3.0M
Mechanisms by which rickettsiae increase microvascular permeabilityR21AI133359 · NIAID · UNIVERSITY OF TEXAS MED BR GALVESTON · PI FANG, RONG MEGAN · 2018 to 2019
$434k
NIAID NIH HHS R21 AI133359NIAID NIH HHS T32 AI060549
6 · The paper itself

Abstract

Rickettsiae are cytosolically replicating, obligately intracellular bacteria causing human infections worldwide with potentially fatal outcomes. We previously showed that

Indexed as

Immunity, InnateAnimalsBacterial LoadCARD Signaling Adaptor ProteinsCells, CulturedDisease Models, AnimalDisease SusceptibilityInflammasomesMacrophagesMice, Inbred C57BLMice, KnockoutRickettsiaSpotted Fever Group RickettsiosisToll-Like Receptor 4CARD Signaling Adaptor ProteinsInflammasomesPycard protein, mouseTlr4 protein, mouseToll-Like Receptor 4ASCinflammasomeLPSrickettsiaeTLR4

Identifiers

PMID32014896
PMCPMC7093143
OpenAlexW3005272676

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.