ArticleJournal of biomechanics2020
Simulating ventricular systolic motion in a four-chamber heart model with spatially varying robin boundary conditions to model the effect of the pericardium.
Article in Journal of biomechanics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers, 1 of them a synthesis that pooled it.
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Who cites it
50 citing papers in PubMed, 1 synthesis or guideline pooled it, 98 citations in OpenAlex.
- Simulating impaired left ventricular-arterial coupling in aging and disease: a systematic review.Biomedical engineering online · 2024Pooled it
- Elucidating the cellular determinants of the end-systolic pressure-volume relationship of the heart via computational modelling.The Journal of physiology · 2026Article
- Cardiac remodelling in type 2 diabetes: Pathophysiological mechanisms and opportunities for multiscale computational modelling and simulation.The Journal of physiology · 2026Review
- Assessing the importance of sex and disease-specific anatomy in electrophysiology and mechanical simulations with a newly developed public virtual cohort of four-chamber heart models.PLoS computational biology · 2026Article
- A finite element computational framework coupling four-chamber heart mechanics with the systemic and pulmonary circulations.Research square · 2026Article
- Coupling Models of Resistive Valves to Muscle Mechanics in Cardiac Fluid-Structure Interaction Simulations.International journal for numerical methods in biomedical engineering · 2025Article
- Inverse analysis of patient-specific parameters of a 3D-0D closed-loop cardiovascular model with an exemplary application to an adult tetralogy of Fallot case.Biomechanics and modeling in mechanobiology · 2025Article
- Regional heterogeneity in left atrial stiffness impacts passive deformation in a cohort of patient-specific models.PLoS computational biology · 2025Article
- Heart in a knot: unraveling the impact of the nested tori myofiber architecture on ventricular mechanics.Biomechanics and modeling in mechanobiology · 2025Article
- Article
- Rhythm control benefits left ventricular function compared with rate control in patients with atrial fibrillation: A computational study.Heart rhythm O2 · 2025Article
- Probabilistic Richardson extrapolation.Journal of the Royal Statistical Society. Series B, Statistical methodology · 2025Article
- Tricuspid valve edge-to-edge repair simulations are highly sensitive to annular boundary conditions.Journal of the mechanical behavior of biomedical materials · 2025Article
- Identification of the Unloaded Heart Configuration Including External Interactions.Functional imaging and modeling of the heart : ... International Workshop, FIMH ..., proceedings. FIMH (Conference) · 2025Article
- Influence of pericardium on ventricular mechanical interdependence in an isolated biventricular working pig heart model.The Journal of physiology · 2025Article
- Personalized computational electro-mechanics simulations to optimize cardiac resynchronization therapy.Biomechanics and modeling in mechanobiology · 2024Article
- Simulating cardiac fluid dynamics in the human heart.PNAS nexus · 2024Article
- Inversion of Left Ventricular Axial Shortening: In Silico Proof of Concept for Treatment of HFpEF.Bioengineering (Basel, Switzerland) · 2024Article
- Computational modeling of cardiac electrophysiology and arrhythmogenesis: toward clinical translation.Physiological reviews · 2024Review
- The Stiffness of the Ascending Aorta Has a Direct Impact on Left Ventricular Function: An In Silico Model.Bioengineering (Basel, Switzerland) · 2024Article
Corrections and comments
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Authors and funding
13 authors at 4 institutions in 3 countries.
Funding
Abstract
The pericardium affects cardiac motion by limiting epicardial displacement normal to the surface. In computational studies, it is important for the model to replicate realistic motion, as this affects the physiological fidelity of the model. Previous computational studies showed that accounting for the effect of the pericardium allows for a more realistic motion simulation. In this study, we describe the mechanism through which the pericardium causes improved cardiac motion. We simulated electrical activation and contraction of the ventricles on a four-chamber heart in the presence and absence of the effect of the pericardium. We simulated the mechanical constraints imposed by the pericardium by applying normal Robin boundary conditions on the ventricular epicardium. We defined a regional scaling of normal springs stiffness based on image-derived motion from CT images. The presence of the pericardium reduced the error between simulated and image-derived end-systolic configurations from 12.8±4.1 mm to 5.7±2.5 mm. First, the pericardium prevents the ventricles from spherising during isovolumic contraction, reducing the outward motion of the free walls normal to the surface and the upwards motion of the apex. Second, by restricting the inward motion of the free and apical walls of the ventricles the pericardium increases atrioventricular plane displacement by four folds during ejection. Our results provide a mechanistic explanation of the importance of the pericardium in physiological simulations of electromechanical cardiac function.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.