ArticleeLife2020
Discovery of several thousand highly diverse circular DNA viruses.
Article in eLife, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 111 papers.
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Who cites it
111 citing papers in PubMed.
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- Eco-evolutionary dynamics of massive, parallel bacteriophage outbreaks in compost communities.Science advances · 2026Article
- The Unified Human Virome Database: A toolkit for expanded human virome analysis.bioRxiv : the preprint server for biology · 2026Article
- CRESSENT: a bioinformatics toolkit to explore and improve ssDNA virus annotation.Microbial genomics · 2026Article
- A comparison of methods for the optimal recovery of the human fecal virome.ISME communications · 2026Article
- Viromics approaches for the study of viral diversity and ecology in microbiomes.Nature reviews. Genetics · 2026Review
- Derailing the host machinery to achieve replication: how viroid and viroid-like RNAs successfully copy their genomes in hostile territory.RNA biology · 2025Review
- Article
- A novel mobile genetic element with virus-like characteristics is widespread in the world's oceans.bioRxiv : the preprint server for biology · 2025Article
- Deciphering the Code of Viral-Host Adaptation Through Maximum-Entropy Nucleotide Bias Models.Molecular biology and evolution · 2025Article
- Penton blooming, a conserved mechanism of genome delivery used by disparate microviruses.mBio · 2025Article
- Population structure and gene flux ofMicrobial genomics · 2025Article
- Virome of Terrestrial Mammals and Bats from Southern Brazil: Circulation of New Putative Members of thePathogens (Basel, Switzerland) · 2025Article
- Article
- Torque Teno Virus: Lights and Shades.Viruses · 2025Review
- Article
- The Spleen Virome of Australia's Endemic Platypus Is Dominated by Highly Diverse Papillomaviruses.Viruses · 2025Article
- Article
- Human papillomavirus in canine serum: evidence from a Chinese study.Frontiers in veterinary science · 2025Article
- Expanding the genomic diversity of human anelloviruses.Virus evolution · 2025Article
51 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
26 authors.
Funding
Abstract
Although millions of distinct virus species likely exist, only approximately 9000 are catalogued in GenBank's RefSeq database. We selectively enriched for the genomes of circular DNA viruses in over 70 animal samples, ranging from nematodes to human tissue specimens. A bioinformatics pipeline, Cenote-Taker, was developed to automatically annotate over 2500 complete genomes in a GenBank-compliant format. The new genomes belong to dozens of established and emerging viral families. Some appear to be the result of previously undescribed recombination events between ssDNA and ssRNA viruses. In addition, hundreds of circular DNA elements that do not encode any discernable similarities to previously characterized sequences were identified. To characterize these 'dark matter' sequences, we used an artificial neural network to identify candidate viral capsid proteins, several of which formed virus-like particles when expressed in culture. These data further the understanding of viral sequence diversity and allow for high throughput documentation of the virosphere.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.