ArticleCritical care (London, England)2020
Impact of a posttraumatic cerebral infarction on outcome in patients with TBI: the Italian multicenter cohort INCEPT study.
Article in Critical care (London, England), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02430324 (Post Traumatic Cerebral Infarction Increases Mortality and Morbidity in Patients With Moderate or Severe Head Trauma. The Multicenter Italian INCEPT), which is not on this map. Cited by 8 papers, 2 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Post Traumatic Cerebral Infarction Increases Mortality and Morbidity in Patients With Moderate or Severe Head Trauma. The Multicenter Italian INCEPT (INfarto CErebrale Post-Traumatico) Study
Who cites it
8 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Guidelines for Neuroprognostication in Critically Ill Adults with Moderate-Severe Traumatic Brain Injury.Neurocritical care · 2024Pooled it
- Comorbidity in traumatic brain injury and functional outcomes: a systematic review.European journal of physical and rehabilitation medicine · 2021Pooled it
- Early Experience With Artificial Intelligence Software to Detect Intracranial Occlusive Stroke in Trauma Patients.Cureus · 2024Article
- Predictors of outcomes 3 to 12 months after traumatic brain injury: a systematic review and meta-analysis.Osong public health and research perspectives · 2024Article
- Changes to the Major Trauma Pre-Hospital Emergency Medical System Network before and during the 2019 COVID-19 Pandemic.Journal of clinical medicine · 2022Article
- Long-Term Risk of Stroke after Traumatic Brain Injury: A Population-Based Medical Record Review Study.Neuroepidemiology · 2022Article
- Effect of New Nursing on Patients with Acute Cerebral Infarction.Computational and mathematical methods in medicine · 2022Article
- Risk Factors for Cerebral Infarction After Moderate or Severe Traumatic Brain Injury.Therapeutics and clinical risk management · 2021Article
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Authors and funding
31 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPost-traumatic cerebral infarction (PTCI) is common after traumatic brain injury (TBI). It is unclear what the occurrence of a PTCI is, how it impacts the long-term outcome, and whether it adds incremental prognostic value to established outcome predictors.
methodsThis was a prospective multicenter cohort study of moderate and severe TBI patients. The primary objective was to evaluate if PTCI was an independent risk factor for the 6-month outcome assessed with the Glasgow Outcome Scale (GOS). We also assessed the PTCI occurrence and if it adds incremental value to the International Mission for Prognosis and Clinical Trial design in TBI (IMPACT) core and extended models.
resultsWe enrolled 143 patients, of whom 47 (32.9%) developed a PTCI. In the multiple ordered logistic regression, PTCI was retained in both the core and extended IMPACT models as an independent predictor of the GOS. The predictive performances increased significantly when PTCI was added to the IMPACT core model (AUC = 0.73, 95% C.I. 0.66-0.82; increased to AUC = 0.79, 95% CI 0.71-0.83, p = 0.0007) and extended model (AUC = 0.74, 95% C.I. 0.65-0.81 increased to AUC = 0.80, 95% C.I. 0.69-0.85; p = 0.00008). Patients with PTCI showed higher ICU mortality and 6-month mortality, whereas hospital mortality did not differ between the two groups.
conclusionsPTCI is a common complication in patients suffering from a moderate or severe TBI and is an independent risk factor for long-term disability. The addition of PTCI to the IMPACT core and extended predictive models significantly increased their performance in predicting the GOS.
trial registrationThe present study was registered in ClinicalTrial.gov with the ID number NCT02430324.
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