Evidence map›Paper›PMID 32014036›Full record

ArticleVirology journal2020

Automated quantification of Epstein-Barr virus in whole blood for post-transplant lymphoproliferative disorders monitoring.

Maud Salmona, Karl Stefic, Nadia Mahjoub, Flore Sicre de Fontbrune, Sarah Maylin, François Simon, Catherine Scieux, Gérard Socié, Marie-Christine Mazeron, Jérôme LeGoff

Open access · goldAbstract readComparative StudyEvaluation Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Virology journal, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Maud SalmonaUniversité de Paris Diderot, INSERM U976, Paris, France. maud.salmona@aphp.fr.ORCID 0000-0001-7985-6132
Karl SteficLaboratoire de Microbiologie, Hôpital Saint-Louis, APHP, Paris, France.
Nadia MahjoubLaboratoire de Microbiologie, Hôpital Saint-Louis, APHP, Paris, France.
Flore Sicre de FontbruneHematology and Transplantation Unit, Hôpital Saint-Louis, APHP, Paris, France.
Sarah MaylinLaboratoire de Microbiologie, Hôpital Saint-Louis, APHP, Paris, France.
François SimonUniversité de Paris Diderot, INSERM U976, Paris, France.
Catherine ScieuxUniversité de Paris Diderot, INSERM U976, Paris, France.
Gérard SociéUniversité de Paris Diderot, INSERM U976, Paris, France.
Marie-Christine MazeronUniversité de Paris Diderot, INSERM U976, Paris, France.
Jérôme LeGoffUniversité de Paris Diderot, INSERM U976, Paris, France.
Inserm · FRAssistance Publique – Hôpitaux de Paris · FRUniversité de Tours · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundStandardized and sensitive assays for Epstein Barr Virus (EBV) are needed to define universal cutoff for treatment initiation in allogeneic hematopoietic stem cells transplant recipients. In a context of accreditation and the availability of EBV international standard, we evaluated the Abbott RealTime EBV (RT) assay for EBV quantification in whole blood.

methodsThe RT assay was compared on 282 prospective clinical samples with the Artus EBV PCR Kit V1 assay (V1) and we analyzed the kinetics of EBV load in 11 patients receiving rituximab treatment.

resultsThe estimated limit of detection was 88 IU/mL. The assay was linear (r

conclusionsIn conclusion, the RT assay is a reliable assay for EBV load in whole blood. Its sensitivity will enable to estimate the kinetics of EBV load and the impact of treatments to control EBV reactivations.

Indexed as

Automation, LaboratoryBloodDNA, ViralEpstein-Barr Virus InfectionsHematopoietic Stem Cell TransplantationHerpesvirus 4, HumanHumansLimit of DetectionLymphoproliferative DisordersProspective StudiesReal-Time Polymerase Chain ReactionRetrospective StudiesSensitivity and SpecificityViral LoadDNA, ViralEBVHematopoietic stem cell transplantMonitoringQuantitative PCRRituximab

Identifiers

PMID32014036
PMCPMC6998838
OpenAlexW3004425297

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.