Observational studyCritical care (London, England)2020
Real-time shear wave ultrasound elastography: a new tool for the evaluation of diaphragm and limb muscle stiffness in critically ill patients.
Observational study in Critical care (London, England), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to 2 registered trials, which are not on this map. Cited by 41 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Muscle Evaluation Using Ultrasound in the Critically Ill : ULTRAMUSCLE Study
Diaphragm Dysfunction and Peripheral Muscle Wasting in Septic Shock Patients: Exploring Their Relationship Over Time Using Ultrasound Technology
Who cites it
41 citing papers in PubMed, 2 syntheses or guidelines pooled it, 64 citations in OpenAlex.
- Reliability and validity of ultrasonography in evaluating the thickness, excursion, stiffness, and strain rate of respiratory muscles in non-hospitalized individuals: a systematic review.BMC oral health · 2023Pooled it
- Characterizing Musculoskeletal Tissue Mechanics Based on Shear Wave Propagation: A Systematic Review of Current Methods and Reported Measurements.Annals of biomedical engineering · 2022Pooled it
- Effects of fentanyl on diaphragm muscle force in patients undergoing knee arthroplasty: a randomised double-blind clinical trial.British journal of anaesthesia · 2026Trial
- Early mechanical changes of limb muscle in septic shock assessed by dual-plane shear-wave elastography.Intensive care medicine experimental · 2026Article
- Assessing hardness to make things easy! Ultrasonography with elastographic evaluation of soft tissue tumours.Journal of ultrasound · 2026Article
- Early Measurement of Quadriceps Response to Neuromuscular Electrical Stimulation to Identify Future ICU-Acquired Weakness.Critical care medicine · 2026Observational
- Reply to: Considerations of emerging diaphragmatic ultrasound techniques for clinical practice: potential pitfalls and future challenges.European respiratory review : an official journal of the European Respiratory Society · 2026Article
- Molecular and Structural Changes, and Skeletal Muscle Strength and Endurance in Chronic Obstructive Pulmonary Disease and Interstitial Lung Disease: Practical Applications of Assessment and Management.Bioengineering (Basel, Switzerland) · 2026Review
- Ultrasound and strain elastography in the intensive care setting for assessment of adult sarcopenia bedside.Journal of ultrasound · 2026Observational
- Noninvasive longitudinal assessment of early-stage Duchenne muscular dystrophy: In vivo diaphragm imaging in mdx mice.Ultrasonics · 2026Article
- Exploring biomechanical differences between brain-first and body-first Parkinson's disease subtypes using shear wave elastography: a pilot cross-sectional study.Frontiers in aging neuroscience · 2026Article
- An ultrasound measurement method for assessing diaphragm mobility during maximal respiration.Scientific reports · 2025Article
- Ultrasound innovations in diaphragm assessment: an integrative review of expanding clinical applications.European respiratory review : an official journal of the European Respiratory Society · 2025Review
- Oropharyngeal ultrafast ultrasound measurements in mechanically ventilated critically ill patients do not identify post-extubation stridor.Critical care (London, England) · 2025Observational
- Analysis of the correlations between ultrasound-assessed diaphragm function and pulmonary function.BMC medical imaging · 2025Article
- Imaging Cancer-associated Cachexia: Utilizing Clinical Imaging Modalities for Early Diagnosis.Radiology. Imaging cancer · 2025Review
- Quantifying Mechanical Properties of the Patellar and Achilles Tendons Using Ultrasound Shear Wave Elastography: A Pilot Study.Diagnostics (Basel, Switzerland) · 2025Article
- Advancements in imaging techniques for monitoring the respiratory muscles.Critical care (London, England) · 2025Review
- Five-Step Knee Adjustment Manipulation Based on the 'Muscle and Bone Balance' Principle for Treating Knee Osteoarthritis: Study Protocol for a Randomized Controlled Trial.Journal of pain research · 2025Article
- Multimodal diaphragmatic ultrasound indicators in healthy adults: reliability and consistency observation by ultrasound physician and critical care physician.Frontiers in medicine · 2025Article
Corrections and comments
- Erratum issued
Authors and funding
13 authors at 7 institutions in 1 country.
Funding
Abstract
backgroundMuscle weakness following critical illness is the consequence of loss of muscle mass and alteration of muscle quality. It is associated with long-term disability. Ultrasonography is a reliable tool to quantify muscle mass, but studies that evaluate muscle quality at the critically ill bedside are lacking. Shear wave ultrasound elastography (SWE) provides spatial representation of soft tissue stiffness and measures of muscle quality. The reliability and reproducibility of SWE in critically ill patients has never been evaluated.
methodsTwo operators tested in healthy controls and in critically ill patients the intra- and inter-operator reliability of the SWE using transversal and longitudinal views of the diaphragm and limb muscles. Reliability was calculated using the intra-class correlation coefficient and a bootstrap sampling method assessed their consistency.
resultsWe collected 560 images. Longitudinal views of the diaphragm (ICC 0.83 [0.50-0.94]), the biceps brachii (ICC 0.88 [0.67-0.96]) and the rectus femoris (ICC 0.76 [0.34-0.91]) were the most reliable views in a training set of healthy controls. Intra-class correlation coefficient for inter-operator reproducibility and intra-operator reliability was above 0.9 for all muscles in a validation set of healthy controls. In critically ill patients, inter-operator reproducibility and intra-operator 1 and 2 reliability ICCs were respectively 0.92 [0.71-0.98], 0.93 [0.82-0.98] and 0.92 [0.81-0.98] for the diaphragm; 0.96 [0.86-0.99], 0.98 [0.94-0.99] and 0.99 [0.96-1] for the biceps brachii and 0.91 [0.51-0.98], 0.97 [0.93-0.99] and 0.99 [0.97-1] for the rectus femoris. The probability to reach intra-class correlation coefficient greater than 0.8 in a 10,000 bootstrap sampling for inter-operator reproducibility was respectively 81%, 84% and 78% for the diaphragm, the biceps brachii and the rectus femoris respectively.
conclusionsSWE is a reliable technique to evaluate limb muscles and the diaphragm in both healthy controls and in critically ill patients.
trial registrationThe study was registered (ClinicalTrial NCT03550222).
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.