Evidence map›Paper›PMID 32013998›Full record

ArticleJournal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance2020

Normal right and left ventricular volumes prospectively obtained from cardiovascular magnetic resonance in awake, healthy, 0- 12 year old children.

Laura J Olivieri, Jiji Jiang, Karin Hamann, Yue-Hin Loke, Adrienne Campbell-Washburn, Hui Xue, Robert McCarter, Russell Cross

Registry-linked trialAbstract readVideo-Audio Media
In one paragraph

Article in Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02892136 (Technical Development for Pediatric Cardiovascular MRI), which is not on this map. Cited by 16 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02892136 active not recruitingnot on this map

Technical Development for Pediatric Cardiovascular MRI

TypeobservationalSponsorChildren's National Research InstituteRan2013 to 2026Enrolled5,000ConditionsCongenital Heart Disease, Cardiovascular Disease
3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Age-, body surface area-, and sex-specific reference values for cardiovascular magnetic resonance imaging derived ventricular and atrial size and function for Chinese healthy children.Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · 2025
    Pooled it
  2. Society for Cardiovascular Magnetic Resonance reference values ("normal values") in cardiovascular magnetic resonance: 2025 update.Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · 2025
    Guideline
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Reference data for left ventricular filling and atrial function in children using cardiovascular magnetic resonance.Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · 2023
    Article
  9. Article
  10. Normative ranges of biventricular volumes and function in healthy term newborns.Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · 2023
    Article
  11. 2021 - State of our JCMR.Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · 2022
    Review
  12. Article
  13. Article
  14. Observational
  15. Small and borderline left ventricular outflow tract - a perplexingIndian journal of thoracic and cardiovascular surgery · 2021
    Review
  16. Lean Mass in Childhood Obesity: A Key Determinant of Ventricular Mass?Journal of the American Heart Association · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Laura J OlivieriDivision of Cardiology, Children's National Medical Center, W3-200, 111 Michigan Ave NW, Washington, DC, 20010, USA. lolivier@childrensnational.org.ORCID 0000-0002-3783-0783
Jiji JiangChildren's Research Institute, Children's National Medical Center, 111 Michigan Ave NW, Washington, DC, USA.
Karin HamannDivision of Cardiology, Children's National Medical Center, W3-200, 111 Michigan Ave NW, Washington, DC, 20010, USA.
Yue-Hin LokeDivision of Cardiology, Children's National Medical Center, W3-200, 111 Michigan Ave NW, Washington, DC, 20010, USA.
Adrienne Campbell-WashburnNational Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA.
Hui XueNational Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA.
Robert McCarterChildren's Research Institute, Children's National Medical Center, 111 Michigan Ave NW, Washington, DC, USA.
Russell CrossDivision of Cardiology, Children's National Medical Center, W3-200, 111 Michigan Ave NW, Washington, DC, 20010, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionPediatric z scores are necessary to describe size and structure of the heart in growing children, however, development of an accurate z score calculator requires robust normal datasets, which are difficult to obtain with cardiovascular magnetic resonance (CMR) in children. Motion-corrected (MOCO) cines from re-binned, reconstructed real-time cine offer a free-breathing, rapid acquisition resulting in cines with high spatial and temporal resolution. In combination with child-friendly positioning and entertainment, MOCO cine technique allows for rapid cine volumetry in patients of all ages without sedation. Thus, our aim was to prospectively enroll normal infants and children birth-12 years for creation and validation of a z score calculator describing normal right ventricular (RV) and left ventricular (LV) size.

methodsWith IRB approval and consent/assent, 149 normal children successfully underwent a brief noncontrast CMR on a 1.5 T scanner including MOCO cines in the short axis, and RV and LV volumes were measured. 20% of scans were re-measured for interobserver variability analyses. A general linear modeling (GLM) framework was employed to identify and properly represent the relationship between CMR-based assessments and anthropometric data. Scatter plots of model fit and Akaike's information criteria (AIC) results were used to guide the choice among alternative models.

resultsA total of 149 subjects aged 22 days-12 years (average 5.1 ± 3.6 years), with body surface area (BSA) range 0.21-1.63 m

conclusionsFree-breathing, MOCO cines allow for accurate, reliable RV and LV volumetry in a wide range of infants and children while awake. Equations predicting fit between LV and RV normal values and BSA are reported herein for purposes of creating z scores.

trial registrationclinicaltrials.gov NCT02892136, Registered 7/21/2016.

Indexed as

Child DevelopmentMagnetic Resonance Imaging, CineVentricular Function, LeftVentricular Function, RightAge FactorsChildChild, PreschoolFemaleHealthy VolunteersHeart VentriclesHumansInfantInfant, NewbornMaleObserver VariationPredictive Value of TestsMotion correction cinePediatric cardiologyVolumetryZ scores

Identifiers

PMID32013998
PMCPMC6998283

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.