ArticleEmerging microbes & infections2020
Delayed recognition of Ebola virus disease is associated with longer and larger outbreaks.
Article in Emerging microbes & infections, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The Impact of Diagnostic Delays and Timeliness of Response on Ebola Disease outbreak-level case-fatality Ratios in Uganda (2000-2023): a Rapid Systematic Review and meta-analysis.Journal of epidemiology and global health · 2025Pooled it
- Underinvestment in diagnostic and vaccine research & development has put the world at greater risk from the Bundibugyo virus epidemic in 2026.Virulence · 2026Article
- How mistrust emerged in real time in the Bundibugyo virus disease outbreak: 'Ebola business', social media and the history of mistrust in Ebola epidemics in eastern Congo.BMJ global health · 2026Article
- Clinical profile and genomic characterization of the 2026 Bundibugyo virus index case in Uganda.Nature medicine · 2026Article
- Exploring the Potential Contribution of Climate-Informed Research to Future Ebola Preparedness in Central Africa.Viruses · 2026Review
- Modeled Scenario Projections for the Ebola Disease Outbreak Caused by Bundibugyo Virus, 2026.MMWR. Morbidity and mortality weekly report · 2026Article
- Links between infrastructure for human movement and early Ebola outbreak trajectories.Scientific reports · 2026Article
- Ebola Virus Disease: Uniquely Challenging Among the Viral Hemorrhagic Fevers.Open forum infectious diseases · 2025Review
- Retrospective case study of the impacts of multiple One Health oriented biocontainment research facilities during the SARS-CoV-2 pandemic.One health (Amsterdam, Netherlands) · 2025Article
- Article
- Geographic Disparities in Domestic Pig Population Exposure to Ebola Viruses, Guinea, 2017-2019.Emerging infectious diseases · 2024Article
- Ebola Virus Tropism in Ex Vivo Cynomolgus Macaque Ocular Tissues.The Journal of infectious diseases · 2023Article
- Disparities in mobile phone ownership reflect inequities in access to healthcare.PLOS digital health · 2023Article
- Evaluation of viral load in patients with Ebola virus disease in Liberia: a retrospective observational study.The Lancet. Microbe · 2022Observational
- Ecology, evolution and spillover of coronaviruses from bats.Nature reviews. Microbiology · 2022Review
- Evaluation of the diagnostic capacities for emerging arboviral diseases in the international network MediLabSecure from 2014 to 2018 - Importance of external quality assessments.Journal of infection and public health · 2022Article
- Molecular analysis of the 2012 Bundibugyo virus disease outbreak.Cell reports. Medicine · 2021Article
- Selenium (Se) plays a key role in the biological effects of some viruses: Implications for COVID-19.Environmental research · 2021Article
- Pacing Forward in the Face of Fragility: Lessons From African Institutions and Governments' Response to Public Health Emergencies.Frontiers in public health · 2021Article
- Article
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Authors and funding
3 authors.
Funding
Abstract
The average time required to detect an Ebola virus disease (EVD) outbreak following spillover of Ebola virus (EBOV) to a primary human case has remained essentially unchanged for over 40 years, with some of the longest delays in detection occurring in recent decades. In this review, our aim was to examine the relationship between delays in detection of EVD and the duration and size of outbreaks, and we report that longer delays are associated with longer and larger EVD outbreaks. Historically, EVD outbreaks have typically been comprised of less than 100 cases (median = 60) and have lasted less than 4 months (median = 118 days). The ongoing outbreak in Democratic Republic of the Congo, together with the 2013-2016 west Africa outbreak, are stark outliers amidst these trends and had two of the longest delays in detection on record. While significant progress has been made in the development of EVD countermeasures, implementation during EVD outbreaks is problematic. Thus, EVD surveillance must be improved by the broad deployment of modern diagnostic tools, as prompt recognition of EVD has the potential to stem early transmission and ultimately limit the duration and size of outbreaks.
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