Evidence map›Paper›PMID 32013736›Full record

ArticleJournal of geriatric psychiatry and neurology2020

Neuropsychiatric Effects on Decision-Making in Early Alzheimer Disease.

Oleg Yerstein, Andrew R Carr, Elvira Jimenez, Mario F Mendez

Abstract read
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In one paragraph

Article in Journal of geriatric psychiatry and neurology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Oleg YersteinVA Greater Los Angeles Healthcare System, Los Angeles, CA, USA.ORCID 0000-0002-9747-053X
Andrew R CarrVA Greater Los Angeles Healthcare System, Los Angeles, CA, USA.
Elvira JimenezVA Greater Los Angeles Healthcare System, Los Angeles, CA, USA.
Mario F MendezVA Greater Los Angeles Healthcare System, Los Angeles, CA, USA.

Funding

Early-Onset Alzheimer's Disease Phenotypes: Neuropsychology and Neural NetworksRF1AG050967 · NIA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI MENDEZ, MARIO F. · 2016 to 2016
$1.9M
Multidisciplinary Study of Social Behavior and Emotion in Frontotemporal DementiaR01AG034499 · NIA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI MENDEZ, MARIO F. · 2009 to 2013
$1.9M
NIA NIH HHS R01 AG034499NIA NIH HHS RF1 AG050967
6 · The paper itself

Abstract

backgroundNeuropsychiatric symptoms can impact decision-making in patients with Alzheimer disease (AD).

methodsUsing a simple decision-making task, a variant of the ultimatum game (UG) modified to control feelings of unfairness, this study investigated rejection responses among responders to unfair offers. The UG was administered to 11 patients with AD, 10 comparably demented patients with behavioral variant frontotemporal dementia (bvFTD), and 9 healthy controls (HC). The results were further compared with differences on the caregiver Neuropsychiatric Inventory (NPI).

resultsOverall, patients with AD significantly rejected more total offers than did the patients with bvFTD and the HC (

conclusionsThese results suggest that early AD can be distinguished based on increased rejections of offers in decision-making, possibly consequent to a heightened sense of unfairness from dysphoria/depression.

Indexed as

Alzheimer DiseaseDecision MakingFemaleHumansMaleMiddle AgedAlzheimer diseasebehavioral variant frontotemporal dementiadecision-makingdementiaemotionultimatum game

Identifiers

PMID32013736
PMCPMC8220792

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.