Evidence map›Paper›PMID 32013704›Full record

ArticleJournal of the American Heart Association2020

Epithelial and Endothelial Adhesion of Immune Cells Is Enhanced by Cardiotonic Steroid Signaling Through Na

Fatimah K Khalaf, Iman Tassavvor, Amal Mohamed, Yiliang Chen, Deepak Malhotra, Zijian Xie, Jiang Tian, Steven T Haller, Kristen Westfall, W H Wilson Tang and 1 more

Open access · goldAbstract read
In one paragraph

Article in Journal of the American Heart Association, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.7field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 12 citations in OpenAlex.

  1. Exploring the Mechanism of NabioRxiv : the preprint server for biology · 2026
    Article
  2. LncDARS-AS1 Regulates ATP1A1 Stability and Enhances NaAdvanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Article
  3. Review
  4. Article
  5. Article
  6. Review
  7. Article
  8. Microcystin-LR (MC-LR) Triggers Inflammatory Responses in Macrophages.International journal of molecular sciences · 2021
    Article
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 1 country.

Fatimah K KhalafUniversity of Toledo College of Medicine and Life Sciences Toledo OH.
Iman TassavvorUniversity of Toledo College of Medicine and Life Sciences Toledo OH.
Amal MohamedUniversity of Toledo College of Medicine and Life Sciences Toledo OH.
Yiliang ChenBlood Research Institute Blood Center of Wisconsin Milwaukee WI.
Deepak MalhotraUniversity of Toledo College of Medicine and Life Sciences Toledo OH.
Zijian XieMarshall Institute for Interdisciplinary Research Marshall University Huntington WV.
Jiang TianUniversity of Toledo College of Medicine and Life Sciences Toledo OH.
Steven T HallerUniversity of Toledo College of Medicine and Life Sciences Toledo OH.
Kristen WestfallDepartment of Cardiovascular and Metabolic Sciences Lerner Research Institute Cleveland Clinic Cleveland OH.
W H Wilson TangDepartment of Cardiovascular and Metabolic Sciences Lerner Research Institute Cleveland Clinic Cleveland OH.
David J KennedyUniversity of Toledo College of Medicine and Life Sciences Toledo OH.
University of Toledo · USCleveland Clinic · USCleveland Clinic Lerner College of Medicine · USMarshall University · USVersiti Blood Center of Wisconsin · US

Funding

Counter regulatory mechanisms of cardiotonic steroids in cardio-renal syndromeR01HL137004 · NHLBI · UNIVERSITY OF TOLEDO HEALTH SCI CAMPUS · PI KENNEDY, DAVID JOSEPH · 2017 to 2021
$1.9M
Na/K-ATPase Reduction in Renal Disease-Related Cardiac DysfunctionR01HL105649 · NHLBI · UNIVERSITY OF TOLEDO HEALTH SCI CAMPUS · PI TIAN, JIANG · 2012 to 2016
$1.8M
American Heart Association-American Stroke Association 17SDG33661117NHLBI NIH HHS R01 HL105649NHLBI NIH HHS R01 HL137004
6 · The paper itself

Abstract

Background Recent studies have highlighted a critical role for a group of natriuretic hormones, cardiotonic steroid (CTS), in mediating renal inflammation and fibrosis associated with volume expanded settings, such as chronic kidney disease. Immune cell adhesion is a critical step in the inflammatory response; however, little is currently understood about the potential regulatory role of CTS signaling in this setting. Herein, we tested the hypothesis that CTS signaling through Na

Indexed as

AnimalsBufanolidesCardiotonic AgentsCell AdhesionCell MovementCoculture TechniquesEndothelial CellsEpithelial CellsHumansKidney Tubules, ProximalLLC-PK1 CellsMacrophages, PeritonealMice, KnockoutRats, Inbred DahlSignal TransductionSodium-Potassium-Exchanging ATPaseATP1A1 protein, humanAtp1a1 protein, mouseAtp1a1 protein, ratBufanolidesCardiotonic AgentsSodium-Potassium-Exchanging ATPasesrc-Family Kinasestelocinobufaginadhesioncardiotonic steroidsmacrophageNa+/K+‐ATPaserenal epitheliumrenal inflammation

Identifiers

PMID32013704
PMCPMC7033897
OpenAlexW3003345262

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.