ArticleCanadian journal of psychiatry. Revue canadienne de psychiatrie2020
Mortality and Revascularization among Myocardial Infarction Patients with Schizophrenia: A Population-Based Cohort Study.
Article in Canadian journal of psychiatry. Revue canadienne de psychiatrie, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
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11 citing papers in PubMed, 1 synthesis or guideline pooled it, 21 citations in OpenAlex.
- Mortality, Revascularization, and Cardioprotective Pharmacotherapy After Acute Coronary Syndrome in Patients With Severe Mental Illness: A Systematic Review and Meta-analysis.Schizophrenia bulletin · 2022Pooled it
- Mental disorders, mortality following myocardial infarction, and the impact of the COVID-19 pandemic in England: a cohort study.European heart journal. Quality of care & clinical outcomes · 2026Article
- Cardiovascular comorbidities in Chinese inpatients with schizophrenia spectrum disorders.Schizophrenia (Heidelberg, Germany) · 2025Article
- In-hospital mortality and cardiovascular treatment during hospitalization for heart failure among patients with schizophrenia: a nationwide cohort study.Epidemiology and psychiatric sciences · 2023Article
- Interaction Between Race, Ethnicity, Severe Mental Illness, and Cardiovascular Disease.Journal of the American Heart Association · 2022Review
- Mortality in people with schizophrenia: a systematic review and meta-analysis of relative risk and aggravating or attenuating factors.World psychiatry : official journal of the World Psychiatric Association (WPA) · 2022Article
- Impaired long-term outcomes of patients with schizophrenia spectrum disorder after coronary artery bypass surgery: nationwide case-control study.BJPsych open · 2022Article
- The Outcomes of Acute Coronary Syndrome in Patients Suffering From Schizophrenia: A Systematic Review.Cureus · 2021Review
- Age Effect on Incidence, Physical, and Psychiatric Comorbidity for Sudden Cardiac Death in Schizophrenia: Effet de l'âge sur l'incidence, la comorbidité physique et psychiatrique de la mort cardiaque subite dans la schizophrénie.Canadian journal of psychiatry. Revue canadienne de psychiatrie · 2021Article
- Severe mental illness and mortality and coronary revascularisation following a myocardial infarction: a retrospective cohort study.BMC medicine · 2021Article
- Cardiovascular disease in patients with severe mental illness.Nature reviews. Cardiology · 2021Review
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Authors and funding
4 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCardiovascular disease is a major source of mortality in schizophrenia, and access to care after acute myocardial infarction (AMI) is poor for these patients.
aimsTo understand the relationship between schizophrenia and access to coronary revascularization and the impact of revascularization on mortality among individuals with schizophrenia and AMI.
methodThis study used a retrospective cohort of AMI in Ontario between 2008 and 2015. The exposure was a diagnosis of schizophrenia, and patients were followed 1 year after AMI discharge. The primary outcome was all-cause mortality within 1 year. Secondary outcomes were cardiac catheterization and revascularization (percutaneous coronary intervention or coronary artery bypass graft). Cox proportional hazard regression models were used to study the relationship between schizophrenia and mortality, and the time-varying effect of revascularization.
resultsA total of 108,610 cases of incident AMI were identified, among whom 1,145 (1.1%) had schizophrenia. Schizophrenia patients had increased mortality, with a hazard ratio (HR) of 1.55 (95% CI, 1.37 to 1.77) when adjusted for age, sex, income, rurality, geographic region, and comorbidity. After adjusting for time-varying revascularization, the HR reduced to 1.38 (95% CI, 1.20 to 1.58). The impact of revascularization on mortality was similar among those with and without schizophrenia (HR: 0.42; 95% CI, 0.41 to 0.44 vs. HR: 0.40; 95% CI, 0.26 to 0.61).
conclusionsIn this sample of AMI, mortality in schizophrenia is increased, and treatment with revascularization reduces the HR of schizophrenia. The higher mortality rate yet similar survival benefit of revascularization among individuals with schizophrenia relative to those without suggests that increasing access to revascularization may reduce the elevated mortality observed in individuals with schizophrenia.
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