Evidence map›Paper›PMID 32013401›Full record

ArticleBiochemistry2020

Subverting Hedgehog Protein Autoprocessing by Chemical Induction of Paracatalysis.

Carl J Smith, Andrew G Wagner, Robert T Stagnitta, Zihan Xu, John L Pezzullo, José-Luis Giner, Jian Xie, Douglas F Covey, Chunyu Wang, Brian P Callahan

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biochemistry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.0field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. There's more to enzyme antagonism than inhibition.Bioorganic & medicinal chemistry · 2023
    Review
  3. Article
  4. Calcimycin InhibitsACS infectious diseases · 2022
    Article
  5. Article
  6. Review
  7. Review
  8. Article
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Carl J SmithDepartment of Chemistry , Binghamton University, State University of New York , 4400 Vestal Parkway East , Binghamton , New York 13902 , United States.
Andrew G WagnerDepartment of Chemistry , Binghamton University, State University of New York , 4400 Vestal Parkway East , Binghamton , New York 13902 , United States.ORCID 0000-0003-4786-7747
Robert T StagnittaDepartment of Chemistry , Binghamton University, State University of New York , 4400 Vestal Parkway East , Binghamton , New York 13902 , United States.
Zihan XuDepartment of Chemistry , Binghamton University, State University of New York , 4400 Vestal Parkway East , Binghamton , New York 13902 , United States.
John L PezzulloDepartment of Chemistry , State University of New York College of Environmental Science and Forestry , Syracuse , New York 13210 , United States.
José-Luis GinerDepartment of Chemistry , State University of New York College of Environmental Science and Forestry , Syracuse , New York 13210 , United States.ORCID 0000-0002-8092-5139
Jian XieDepartment of Biological Sciences, Center for Biotechnology and Interdisciplinary Studies , Rensselaer Polytechnic Institute , 110 8th Street , Troy , New York 12180 , United States.
Douglas F CoveyDepartment of Developmental Biology , Taylor Family Institute for Innovative Psychiatric Research , 660 South Euclid Avenue , St. Louis , Missouri 63110 , United States.
Chunyu WangDepartment of Biological Sciences, Center for Biotechnology and Interdisciplinary Studies , Rensselaer Polytechnic Institute , 110 8th Street , Troy , New York 12180 , United States.ORCID 0000-0001-5165-7959
Brian P CallahanDepartment of Chemistry , Binghamton University, State University of New York , 4400 Vestal Parkway East , Binghamton , New York 13902 , United States.ORCID 0000-0003-4826-0162
Binghamton University · USRensselaer Polytechnic Institute · USState University of New York · USTaylor Family Institute for Innovative Psychiatric Research

Funding

Structural Mechanisms of Hedgehog Autoprocessing in Physiology and DiseaseR01CA206592 · NCI · RENSSELAER POLYTECHNIC INSTITUTE · PI CALLAHAN, BRIAN PATRICK, WANG, CHUNYU · 2017 to 2021
$2.0M
A 800 MHz Nuclear Magnetic Resonance Spectrometer in Support of Life Science ReseS10OD012254 · OD · UPSTATE MEDICAL UNIVERSITY · PI WILKENS, STEPHAN · 2013 to 2013
$2.0M
Predoctoral Training Program for Alzheimer’s Disease at the Interface of Data Science, Engineering and BiologyT32AG078123 · NIA · RENSSELAER POLYTECHNIC INSTITUTE · PI Chunyu Wang · 2023 to 2026
$974k
NCI NIH HHS R01 CA206592NIA NIH HHS T32 AG078123NIH HHS S10 OD012254
6 · The paper itself

Abstract

Hedgehog proteins, a family of vital cell signaling factors, are expressed in precursor form, which requires specialized autoprocessing, called cholesterolysis, for full biological activity. Cholesterolysis occurs

Indexed as

CatalysisCholesterolDrosophila ProteinsGenetic VariationHedgehog ProteinsProteolysisCholesterolDrosophila ProteinsHedgehog Proteins

Identifiers

PMID32013401
PMCPMC7031038
OpenAlexW3005075581

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.