ArticleACS applied materials & interfaces2020
Controlled Delivery of Curcumin and Vitamin K2 from Hydroxyapatite-Coated Titanium Implant for Enhanced in Vitro Chemoprevention, Osteogenesis, and in Vivo Osseointegration.
Article in ACS applied materials & interfaces, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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The trial behind it
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Who cites it
36 citing papers in PubMed, 87 citations in OpenAlex.
- Mechanically adaptive Mg-Ti composites guided by single-cell insights accelerate load-bearing bone regeneration via dual modulation of osteogenesis and osteoclastogenesis.Bioactive materials · 2026Article
- ZnO-Hydroxyapatite-Coated Ti-6Al-4V With Curcumin and Ginger Extract for Load-Bearing Implants.Journal of the American Ceramic Society. American Ceramic Society · 2026Article
- Enhanced Osseointegration, Osteogenic Differentiation and Adherence Behaviour of Healthy Human Osteoblasts on a Roughened Titanium Surface by Vitamin K2 and Vitamin D3.Materials (Basel, Switzerland) · 2025Article
- EnhancedACS applied bio materials · 2025Article
- Tannic Acid-Loaded Antibacterial Hydroxyapatite-Zirconia Composite for Dental Applications.Crystals · 2025Article
- Curcumin and vitamin D3 release from calcium phosphate enhances bone regeneration.Biomaterials science · 2025Article
- Emerging Strategies for Bioactive Agent-Loaded Xenogeneic Bone Scaffolds in Regenerative Medicine: A Comprehensive Review.Drug design, development and therapy · 2025Review
- Bone Healing via Carvacrol and Curcumin Nanoparticle on 3D Printed Scaffolds.Small (Weinheim an der Bergstrasse, Germany) · 2024Article
- The Effectiveness of Curcumin Nanoparticle-Coated Titanium Surfaces in Osteogenesis: A Systematic Review.Journal of functional biomaterials · 2024Review
- Modified Titanium Surface with Nano Amorphous Calcium Phosphate@Chitosan Oligolactate as Ion Loading Platform with Multifunctional Properties for Potential Biomedical Application.Annals of biomedical engineering · 2024Article
- Stimuli-Responsive Codelivery System-Embedded Polymeric Nanofibers with Synergistic Effects of Growth Factors and Low-Intensity Pulsed Ultrasound to Enhance Osteogenesis Properties.ACS applied bio materials · 2024Article
- Bioactive Glasses Modulate Anticancer Activity and Other Polyphenol-Related Properties of Polyphenol-Loaded PCL/Bioactive Glass Composites.ACS applied materials & interfaces · 2024Article
- Vitamin D3 Release from MgO Doped 3D Printed TCP Scaffolds for Bone Regeneration.ACS biomaterials science & engineering · 2024Article
- Curcumin and Vitamin C dual release from Hydroxyapatite coated Ti6Al4V discs enhancesMaterials chemistry and physics · 2024Article
- Evaluation of sustained drug release performance and osteoinduction of magnetron-sputtered tantalum-coated titanium dioxide nanotubes.RSC advances · 2024Article
- Natural medicine delivery from 3D printed bone substitutes.Journal of controlled release : official journal of the Controlled Release Society · 2024Review
- Hydroxyapatite coated titanium with curcumin and epigallocatechin gallate for orthopedic and dental applications.Biomaterials advances · 2023Article
- Micelle encapsulated curcumin and piperine-laden 3D printed calcium phosphate scaffolds enhance in vitro biological properties.Colloids and surfaces. B, Biointerfaces · 2023Article
- Multifunctional polydopamine - ZnBiomaterials advances · 2023Article
- Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Successful repair of critical-sized tumor-resection defects, especially in load-bearing bones, still remains a major challenge in clinical orthopedics. Titanium (Ti) implants have been increasingly used in the past few decades because of titanium's suitable mechanical properties and biocompatibility; however, it shows insufficient integration with the surrounding bone. In this study, the plasma spray technique is utilized to form homogeneous hydroxyapatite (HA) coating on the surface of the Ti implant to enhance osseointegration at the tissue-implant interface. These coated implants are loaded with curcumin and vitamin K2 to introduce chemopreventive and osteogenesis ability via controlled release of these biomolecules. The synergistic effect of these two biomolecules showed enhanced in vitro osteoblast (hFOB) cell attachment and proliferation for 11 days. Moreover, these biomolecules showed lower in vitro osteosarcoma (MG-63) cell proliferation after 3, 7, and 11 days. An in vivo study was carried out to evaluate the bone bonded zone in a rat distal femur model at an early wound healing stage of 5 days. Modified Masson Goldner staining of the tissue-implant section showed improved contact between tissue and implant in dual drug-loaded HA-coated Ti implants compared to control implants. This work presents a successful fabrication of a mechanically competent functional Ti implant with the advantages of enhanced in vitro osteoblast proliferation, osteosarcoma inhibition, and in vivo osseointegration, indicating the potential for load-bearing bone-defect repair after tumor resection.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.