ArticleInternational journal of molecular sciences2020
Optimization of Chitosan-Alginate Microparticles for Delivery of Mangostins to the Colon Area Using Box-Behnken Experimental Design.
Article in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 33 citations in OpenAlex.
- Coordination-Driven Assembly of Alginate Networks: From Egg-Box Structures to Bioactive Delivery Applications.Gels (Basel, Switzerland) · 2026Review
- Structure-Property Relationships Governing Encapsulation and Release of Antibiotics from Calcium-Alginate Hydrogels.Gels (Basel, Switzerland) · 2026Article
- Preparation, Characterization, and In Vitro Digestion Behavior of Alginate-Chitosan Microspheres Loaded withFoods (Basel, Switzerland) · 2026Article
- Development of Artocarpin-Loaded Chitosan Particles for Controlled Release and Inflammatory Application.Polymers · 2025Article
- Advances in polysaccharide-based biopolymers for probiotic encapsulation: From single polysaccharides to composite systems.Current research in food science · 2025Review
- Chitosan-Based Nanoformulations: Preclinical Investigations, Theranostic Advancements, and Clinical Trial Prospects for Targeting Diverse Pathologies.AAPS PharmSciTech · 2024Review
- Multi-layer encapsulation of pumpkin (Heliyon · 2024Article
- Stabilization of Black Locust Flower Extract via Encapsulation Using Alginate and Alginate-Chitosan Microparticles.Polymers · 2024Article
- Preparation, Physicochemical Characterization, and Antioxidant Activity of Naringin-Silk Fibroin-Alginate Microspheres and Application in Yogurt.Foods (Basel, Switzerland) · 2022Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Chitosan-alginate microparticles loaded with hydrophobic mangostins present in the mangosteen rind extract have been formulated and optimized for colon-targeted bioactive drug delivery systems. The chitosan-mangostin microparticles were prepared using the ionotropic gelation method with sodium tripolyphosphate as the cross-linking agent of chitosan. The chitosan-mangostin microparticles were then encapsulated in alginate with calcium chloride as the linking agent. The mangostin release profile was optimized using the Box-Behnken design for response surface methodology with three independent variables: (A) chitosan-mangostin microparticle size, (B) alginate:chitosan mass ratio, and (C) concentration of calcium chloride. The following representative equation was obtained: percent cumulative release of mangostins (10 h) = 59.51 - 5.16A + 20.00B - 1.27C - 1.70AB - 5.43AC - 5.04BC + 0.0579A
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Registered trials
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