Evidence map›Paper›PMID 32013182›Full record

ArticleInternational journal of molecular sciences2020

Molecular Interactions of Carbapenem Antibiotics with the Multidrug Efflux Transporter AcrB of

Alessio Atzori, Giuliano Malloci, Francesca Cardamone, Andrea Bosin, Attilio Vittorio Vargiu, Paolo Ruggerone

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.0field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 15 citations in OpenAlex.

  1. Potato (Molecules (Basel, Switzerland) · 2026
    Article
  2. Review
  3. Article
  4. Article
  5. The Art of War withAntibiotics (Basel, Switzerland) · 2023
    Review
  6. Review
  7. Article
  8. Insights into Carbapenem Resistance inInternational journal of molecular sciences · 2022
    Review
  9. Review
  10. MexAB-OprM Efflux Pump Interaction with the Peptidoglycan ofInternational journal of molecular sciences · 2021
    Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Alessio AtzoriDepartment of Physics, University of Cagliari, 09042 Monserrato (CA), Italy.
Giuliano MallociDepartment of Physics, University of Cagliari, 09042 Monserrato (CA), Italy.ORCID 0000-0002-5985-257X
Francesca CardamoneDepartment of Physics, University of Cagliari, 09042 Monserrato (CA), Italy.
Andrea BosinDepartment of Physics, University of Cagliari, 09042 Monserrato (CA), Italy.ORCID 0000-0001-6300-5712
Attilio Vittorio VargiuDepartment of Physics, University of Cagliari, 09042 Monserrato (CA), Italy.ORCID 0000-0003-4013-8867
Paolo RuggeroneDepartment of Physics, University of Cagliari, 09042 Monserrato (CA), Italy.
University of Cagliari · IT

Funding

Optimization of efflux avoidance and inhibition for antibiotic developmentR01AI136799 · NIAID · UNIVERSITY OF OKLAHOMA · PI GNANAKARAN, SANDRASEGARAM, RUGGERONE, PAOLO · 2018 to 2022
$5.7M
Innovative Medicines Initiative 115525National Institute of Allergy and Infectious Diseases AI136799
6 · The paper itself

Abstract

The drug/proton antiporter AcrB, engine of the major efflux pump AcrAB(Z)-TolC of

Indexed as

Anti-Bacterial AgentsATP-Binding Cassette, Sub-Family C ProteinsBinding SitesCarbapenemsDrug Resistance, Multiple, BacterialEscherichia coliEscherichia coli ProteinsMolecular Docking SimulationMolecular Dynamics SimulationProtein BindingThermodynamicsAcrB protein, E coliAnti-Bacterial AgentsATP-Binding Cassette, Sub-Family C ProteinsCarbapenemsEscherichia coli ProteinsAcrBantibiotic resistancebinding free energy calculationsGram-negative bacteriamolecular dockingmolecular dynamics simulationsresistance nodulation-cell division transporters

Identifiers

PMID32013182
PMCPMC7037162
OpenAlexW3004407485

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.