Evidence map›Paper›PMID 32013144›Full record

ArticleViruses2020

Comparison of the Pathogenicity in Mice of A(H1N1)pdm09 Viruses Isolated between 2009 and 2015 in Japan.

Hiromichi Mitake, Atsuhiro Yasuhara, Tiago J S Lopes, Yuko Tagawa-Sakai, Kohei Shimizu, Hiroki Ozawa, Chiharu Kawakami, Saeko Morikawa, Norio Sugaya, Tokiko Watanabe and 1 more

Open access · goldAbstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Viruses, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact, top 99% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 2 countries.

Hiromichi MitakeDivision of Virology, Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo, Tokyo 108-8639, Japan.
Atsuhiro YasuharaDivision of Virology, Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo, Tokyo 108-8639, Japan.
Tiago J S LopesDepartment of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, WI 53711, USA.
Yuko Tagawa-SakaiDivision of Virology, Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo, Tokyo 108-8639, Japan.
Kohei ShimizuYokohama City Institute of Public Health, Kanagawa 236-0051, Japan.
Hiroki OzawaYokohama City Institute of Public Health, Kanagawa 236-0051, Japan.
Chiharu KawakamiYokohama City Institute of Public Health, Kanagawa 236-0051, Japan.
Saeko MorikawaDivision of Virology, Department of Microbiology, Osaka Institute of Public Health, Osaka 537-0025, Japan.
Norio SugayaDepartment of Infection Control and Pediatrics, Keiyu Hospital, Yokohama 220-0012, Japan.
Tokiko WatanabeDivision of Virology, Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo, Tokyo 108-8639, Japan.
Yoshihiro KawaokaDivision of Virology, Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo, Tokyo 108-8639, Japan.
The University of Tokyo · JPKanagawa Prefectural Institute of Public Health · JPUniversity of Wisconsin–Madison · USkeiyu Hospital · JPOsaka Prefectural Institute of Public Health · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The A(H1N1)pdm09 virus emerged in 2009 and continues to circulate in human populations. Recent A(H1N1)pdm09 viruses, that is, A(H1N1)pdm09 viruses circulating in the post-pandemic era, can cause more or less severe infections than those caused by the initial pandemic viruses. To evaluate the changes in pathogenicity of the A(H1N1)pdm09 viruses during their continued circulation in humans, we compared the nucleotide and amino acid sequences of ten A(H1N1)pdm09 viruses isolated in Japan between 2009 and 2015, and experimentally infected mice with each virus. The severity of infection caused by these Japanese isolates ranged from milder to more severe than that caused by the prototypic pandemic strain A/California/04/2009 (CA04/09); however, specific mutations responsible for their pathogenicity have not yet been identified.

Indexed as

Amino Acid SequenceBase SequenceAnimalsFemaleHumansInfluenza A Virus, H1N1 SubtypeInfluenza, HumanJapanMiceMice, Inbred BALB CMutationOrthomyxoviridae InfectionsPandemicsPhylogenyRNA, ViralSeverity of Illness IndexRNA, Viralinfluenzapandemic viruspathogenicity

Identifiers

PMID32013144
PMCPMC7077310
OpenAlexW3004054675

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.