Evidence map›Paper›PMID 32013098›Full record

ArticleCancers2020

Dephosphorylation of YB-1 is Required for Nuclear Localisation During G

Sunali Mehta, Cushla McKinney, Michael Algie, Chandra S Verma, Srinivasaraghavan Kannan, Rhodri Harfoot, Tara K Bartolec, Puja Bhatia, Alistair J Fisher, Maree L Gould and 7 more

Open access · goldAbstract read
In one paragraph

Article in Cancers, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 24 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. YB-1 activating cascades as potential targets in KRAS-mutated tumors.Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] · 2023
    Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Karyopherin-mediated nucleocytoplasmic transport.Nature reviews. Molecular cell biology · 2022
    Review
  14. Review
  15. YB-1 Phosphorylation at Serine 209 Inhibits Its Nuclear Translocation.International journal of molecular sciences · 2021
    Article
  16. High salt diet-induced proximal tubular phenotypic changes and sodium-glucose cotransporter-2 expression are coordinated by cold shock Y-box binding protein-1.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2021
    Article
  17. Article
  18. Review
  19. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 5 institutions in 4 countries.

Sunali MehtaDepartment of Pathology, University of Otago, PO Box 56, Dunedin 9016, New Zealand.
Cushla McKinneyDepartment of Pathology, University of Otago, PO Box 56, Dunedin 9016, New Zealand.
Michael AlgieDepartment of Pathology, University of Otago, PO Box 56, Dunedin 9016, New Zealand.
Chandra S VermaBioinformatics Institute (A*STAR), 30 Biopolis Street, 07-01 Matrix, Singapore 138671, Singapore.
Srinivasaraghavan KannanBioinformatics Institute (A*STAR), 30 Biopolis Street, 07-01 Matrix, Singapore 138671, Singapore.
Rhodri HarfootDepartment of Pathology, University of Otago, PO Box 56, Dunedin 9016, New Zealand.
Tara K BartolecChildren's Medical Research Institute, University of Sydney, NSW 2145, Australia.
Puja BhatiaDepartment of Pathology, University of Otago, PO Box 56, Dunedin 9016, New Zealand.
Alistair J FisherDepartment of Pathology, University of Otago, PO Box 56, Dunedin 9016, New Zealand.
Maree L GouldDepartment of Pathology, University of Otago, PO Box 56, Dunedin 9016, New Zealand.
Kim ParkerDepartment of Pathology, University of Otago, PO Box 56, Dunedin 9016, New Zealand.
Anthony J CesareChildren's Medical Research Institute, University of Sydney, NSW 2145, Australia.
Heather E CunliffeDepartment of Pathology, University of Otago, PO Box 56, Dunedin 9016, New Zealand.
Scott B CohenChildren's Medical Research Institute, University of Sydney, NSW 2145, Australia.
Torsten KleffmannCentre for Protein Research, Department of Biochemistry, University of Otago, PO Box 56, Dunedin 9016, New Zealand.
Antony W BraithwaiteDepartment of Pathology, University of Otago, PO Box 56, Dunedin 9016, New Zealand.
Adele G WoolleyDepartment of Pathology, University of Otago, PO Box 56, Dunedin 9016, New Zealand.
University of Otago · NZThe University of Sydney · AUAgency for Science, Technology and Research · SGMaurice Wilkins Centre · NZMalaghan Institute of Medical Research · NZ

Funding

Cancer Society of New Zealand 11/07NHMRC Australia 1053195NHMRC Australia 1106241
6 · The paper itself

Abstract

Elevated levels of nuclear Y-box binding protein 1 (YB-1) are linked to poor prognosis in cancer. It has been proposed that entry into the nucleus requires specific proteasomal cleavage. However, evidence for cleavage is contradictory and high YB-1 levels are prognostic regardless of cellular location. Here, using confocal microscopy and mass spectrometry, we find no evidence of specific proteolytic cleavage. Doxorubicin treatment, and the resultant G

Indexed as

atomistic modellingcell cyclenuclear translocationphosphorylationYB-1

Identifiers

PMID32013098
PMCPMC7072210
OpenAlexW3004201943

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.