Evidence map›Paper›PMID 32013071›Full record

ArticlePolymers2020

Jet Cutting Technique for the Production of Chitosan Aerogel Microparticles Loaded with Vancomycin.

Clara López-Iglesias, Joana Barros, Inés Ardao, Pavel Gurikov, Fernando J Monteiro, Irina Smirnova, Carmen Alvarez-Lorenzo, Carlos A García-González

Open access · goldAbstract read
In one paragraph

Article in Polymers, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
4.6field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 53 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 3 countries.

Clara López-IglesiasDepartment of Pharmacology, Pharmacy and Pharmaceutical Technology, I+D Farma group (GI-1645), Faculty of Pharmacy, Agrupación Estratégica de Materiales (AeMAT) and Health Research Institute of Santiago de Compostela (IDIS), Universidade de Santiago de Compostela, E-15782 Santiago de Compostela, Spain.
Joana BarrosInstituto de Investigação e Inovação em Saúde (i3S), Instituto Nacional de Engenharia Biomédica (INEB) and Faculdade de Engenharia Universidade do Porto (FEUP), Universidade do Porto, 4200-135 Porto, Portugal.
Inés ArdaoBioFarma Research group, Center for Research in Molecular Medicine and Chronic Diseases (CiMUS), Universidade de Santiago de Compostela, E-15782 Santiago de Compostela, Spain.
Pavel GurikovLaboratory for Development and Modelling of Novel Nanoporous Materials, Eißendorfer Str. 38, 21073 Hamburg, Germany.
Fernando J MonteiroInstituto de Investigação e Inovação em Saúde (i3S), Instituto Nacional de Engenharia Biomédica (INEB) and Faculdade de Engenharia Universidade do Porto (FEUP), Universidade do Porto, 4200-135 Porto, Portugal.
Irina SmirnovaInstitute of Thermal Separation Processes, Hamburg University of Technology, Eißendorfer Str. 38, 21073 Hamburg, Germany.
Carmen Alvarez-LorenzoDepartment of Pharmacology, Pharmacy and Pharmaceutical Technology, I+D Farma group (GI-1645), Faculty of Pharmacy, Agrupación Estratégica de Materiales (AeMAT) and Health Research Institute of Santiago de Compostela (IDIS), Universidade de Santiago de Compostela, E-15782 Santiago de Compostela, Spain.
Carlos A García-GonzálezDepartment of Pharmacology, Pharmacy and Pharmaceutical Technology, I+D Farma group (GI-1645), Faculty of Pharmacy, Agrupación Estratégica de Materiales (AeMAT) and Health Research Institute of Santiago de Compostela (IDIS), Universidade de Santiago de Compostela, E-15782 Santiago de Compostela, Spain.
Universidade de Santiago de Compostela · ESi3S - Instituto de Investigação e Inovação em Saúde, Universidade do Porto · PTNovel (Germany) · DEUniversität Hamburg · DE

Funding

Agencia Estatal de Investigación AEIEuropean Cooperation in Science and Technology CA18125European Regional Development Fund FEDERMinisterio de Ciencia, Innovación y Universidades RTI2018-094131-A-I00Ministerio de Economía y Competitividad RYC2014-15239Xunta de Galicia ED431C 2016/008Xunta de Galicia ED431E 2018/08Xunta de Galicia ED431F 2016/010
6 · The paper itself

Abstract

Biopolymer-based aerogels can be obtained by supercritical drying of wet gels and endowed with outstanding properties for biomedical applications. Namely, polysaccharide-based aerogels in the form of microparticles are of special interest for wound treatment and can also be loaded with bioactive agents to improve the healing process. However, the production of the precursor gel may be limited by the viscosity of the polysaccharide initial solution. The jet cutting technique is regarded as a suitable processing technique to overcome this problem. In this work, the technological combination of jet cutting and supercritical drying of gels was assessed to produce chitosan aerogel microparticles loaded with vancomycin HCl (antimicrobial agent) for wound healing purposes. The resulting aerogel formulation was evaluated in terms of morphology, textural properties, drug loading, and release profile. Aerogels were also tested for wound application in terms of exudate sorption capacity, antimicrobial activity, hemocompatibility, and cytocompatibility. Overall, the microparticles had excellent textural properties, absorbed high amounts of exudate, and controlled the release of vancomycin HCl, providing sustained antimicrobial activity.

Indexed as

aerogelsbiomedical applicationsbiopolymerschitosanpolymer processingwound treatment

Identifiers

PMID32013071
PMCPMC7077406
OpenAlexW3003700023

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.