Evidence map›Paper›PMID 32013056›Full record

ArticlePharmaceutics2020

Molecular Mechanisms of the Interactions of

Larisa Janisova, Andrey Gruzinov, Olga V Zaborova, Nadiia Velychkivska, Ondřej Vaněk, Petr Chytil, Tomáš Etrych, Olga Janoušková, Xiaohan Zhang, Clement Blanchet and 3 more

Open access · goldAbstract read
In one paragraph

Article in Pharmaceutics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.1field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 16 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Review
  5. Article
  6. Polymer nanomedicines.Advanced drug delivery reviews · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 6 institutions in 4 countries.

Larisa JanisovaInstitute of Macromolecular Chemistry, Czech Academy of Sciences, Heyrovského sq. 2, 16206 Prague, Czech Republic.
Andrey GruzinovEuropean Molecular Biology Laboratory, Deutsches Elektronen-Synchrotron, Notkestr. 85, 22607 Hamburg, Germany.
Olga V ZaborovaInstitute of Macromolecular Chemistry, Czech Academy of Sciences, Heyrovského sq. 2, 16206 Prague, Czech Republic.
Nadiia VelychkivskaInstitute of Macromolecular Chemistry, Czech Academy of Sciences, Heyrovského sq. 2, 16206 Prague, Czech Republic.
Ondřej VaněkDepartment of Biochemistry, Faculty of Science, Charles University, Hlavova 2030/8, 12840 Prague, Czech Republic.
Petr ChytilInstitute of Macromolecular Chemistry, Czech Academy of Sciences, Heyrovského sq. 2, 16206 Prague, Czech Republic.
Tomáš EtrychInstitute of Macromolecular Chemistry, Czech Academy of Sciences, Heyrovského sq. 2, 16206 Prague, Czech Republic.
Olga JanouškováInstitute of Macromolecular Chemistry, Czech Academy of Sciences, Heyrovského sq. 2, 16206 Prague, Czech Republic.
Xiaohan ZhangFachgebiet Physik weicher Materie, Physik-Department, Technische Universität München, James-Franck-Str. 1, 85748 Garching, Germany.
Clement BlanchetEuropean Molecular Biology Laboratory, Deutsches Elektronen-Synchrotron, Notkestr. 85, 22607 Hamburg, Germany.
Christine M PapadakisFachgebiet Physik weicher Materie, Physik-Department, Technische Universität München, James-Franck-Str. 1, 85748 Garching, Germany.
Dmitri I SvergunEuropean Molecular Biology Laboratory, Deutsches Elektronen-Synchrotron, Notkestr. 85, 22607 Hamburg, Germany.
Sergey K FilippovHarvard John A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, MA 02138, USA.
Czech Academy of Sciences, Institute of Macromolecular Chemistry · CZDeutsches Elektronen-Synchrotron DESY · DETechnical University of Munich · DECharles University · CZHarvard University · USLomonosov Moscow State University · RU

Funding

Deutsche Forschungsgemeinschaft Pa771/17-1Grantová Agentura České Republiky 15-10527JGrantová Agentura České Republiky 17-009735Grantová Agentura České Republiky 17-13283SGrantová Agentura, Univerzita Karlova UNCE 204025/2012Ministry of Education, Youth and Sports of CR POLYMAT LO1507Ministry of Education, Youth and Sports of the Czech Republic LTC17065
6 · The paper itself

Abstract

The binding of plasma proteins to a drug carrier alters the circulation of nanoparticles (NPs) in the bloodstream, and, as a consequence, the anticancer efficiency of the entire nanoparticle drug delivery system. We investigate the possible interaction and the interaction mechanism of a polymeric drug delivery system based on

Indexed as

drug deliverypHPMAplasma proteinspolymeric nanoparticlesstealth effect

Identifiers

PMID32013056
PMCPMC7076460
OpenAlexW3003533868

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.