Evidence map›Paper›PMID 32013053›Full record

ArticleInternational journal of molecular sciences2020

Deletion of the Nucleotide Exchange Factor Vav3 Enhances Axonal Complexity and Synapse Formation but Tampers Activity of Hippocampal Neuronal Networks In Vitro.

David Wegrzyn, Christine Wegrzyn, Kerry Tedford, Klaus-Dieter Fischer, Andreas Faissner

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.3field-weighted citation impact, top 51% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 9 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

David WegrzynDepartment of Cell Morphology and Molecular Neurobiology, Ruhr-University Bochum, Universitaetsstr. 150, Ruhr-University, D-44801 Bochum, Germany.
Christine WegrzynDepartment of Cell Morphology and Molecular Neurobiology, Ruhr-University Bochum, Universitaetsstr. 150, Ruhr-University, D-44801 Bochum, Germany.
Kerry TedfordInstitute of Biochemistry and Cell Biology, OVGU University of Magdeburg, Leipziger Str. 44, D-39120 Magdeburg, Germany.
Klaus-Dieter FischerInstitute of Biochemistry and Cell Biology, OVGU University of Magdeburg, Leipziger Str. 44, D-39120 Magdeburg, Germany.
Andreas FaissnerDepartment of Cell Morphology and Molecular Neurobiology, Ruhr-University Bochum, Universitaetsstr. 150, Ruhr-University, D-44801 Bochum, Germany.
Ruhr University Bochum · DEUniversity Hospital Magdeburg · DE

Funding

Deutsche Forschungsgemeinschaft SFB 642 TPA24; FA 159/22-1
6 · The paper itself

Abstract

Vav proteins activate GTPases of the RhoA subfamily that regulate the cytoskeleton and are involved in adhesion, migration, differentiation, polarity and the cell cycle. While the importance of RhoA GTPases for neuronal morphology is undisputed, their regulation is less well understood. In this perspective, we studied the consequences of the deletion of

Indexed as

Action PotentialsAnimalsAstrocytesCell DifferentiationCells, CulturedCoculture TechniquesFemaleGene Knockout TechniquesHippocampusMaleMiceNeuronsProto-Oncogene Proteins c-vavTissue Array AnalysisProto-Oncogene Proteins c-vavVav3 protein, mouseaxon growthdendrite growthguanine nucleotide exchange factorMAP2multielectrode array (MEA)Rac1RhoA familyTauVav proteins

Identifiers

PMID32013053
PMCPMC7037001
OpenAlexW3003744609

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.