ArticleJournal of clinical medicine2020
Central Resistance to Thyroid Hormones in Morbidly Obese Subjects Is Reversed after Bariatric Surgery-Induced Weight Loss.
Article in Journal of clinical medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 43 citations in OpenAlex.
- Low Preoperative Free Triiodothyronine, Particularly in Females, Is Associated With Reduced Weight Loss and Diabetes Remission After Bariatric Surgery in Euthyroid Adults.Diabetes/metabolism research and reviews · 2026Article
- Effectiveness of Bariatric Surgery Versus Nutritional Interventions in Adolescents: A Retrospective Cohort Study.Obesity surgery · 2026Article
- Impaired central thyroid hormone sensitivity is associated with time in range in patients with type 2 diabetes mellitus in the euthyroid population.Diabetology & metabolic syndrome · 2025Article
- Impaired central sensitivity to thyroid hormone is associated with hypertriglyceridemia in euthyroid population.Frontiers in endocrinology · 2025Article
- Effect of Laparoscopic Sleeve Gastrectomy on Hypothyroidism in Patients with Morbid Obesity: A one-year follow-up Prospective Cohort Study.Iranian journal of pathology · 2025Article
- Association of Sensitivity to Thyroid Hormones and Non-Alcoholic Fatty Liver Disease and the Severity of Liver Fibrosis in Euthyroid Adults: A Retrospective Study.Diabetes, metabolic syndrome and obesity : targets and therapy · 2025Article
- Association between sensitivity to thyroid hormones and trabecular bone score in euthyroid individuals: a population-based cross-sectional study.BMC musculoskeletal disorders · 2024Article
- Obesity and Obesity-Related Thyroid Dysfunction: Any Potential Role for the Very Low-Calorie Ketogenic Diet (VLCKD)?Current nutrition reports · 2024Review
- Relationship between Thyroid Feedback Quantile-based Index and cardiovascular diseases in a population with normal thyroid function: Evidence from the National Health and Nutrition Examination Survey 2007-2012.Clinical cardiology · 2024Article
- Subclinical Hypothyroidism in Patients with Obesity and Metabolic Syndrome: A Narrative Review.Nutrients · 2023Review
- Maternal pre-pregnancy obesity modifies the association between first-trimester thyroid hormone sensitivity and gestational Diabetes Mellitus: a retrospective study from Northern China.Diabetology & metabolic syndrome · 2023Article
- Sensitivity to thyroid hormone indices are associated with papillary thyroid carcinoma in Chinese patients with thyroid nodules.BMC endocrine disorders · 2023Article
- Article
- Association between sensitivity to thyroid hormones and dyslipidemia in patients with coronary heart disease.Endocrine · 2023Article
- Levothyroxine therapy, calculated deiodinases activity and basal metabolic rate in obese or nonobese patients after total thyroidectomy for differentiated thyroid cancer, results of a retrospective observational study.Endocrinology, diabetes & metabolism · 2023Observational
- Association between High Normal TSH Levels and Obesity in Women with Anti-Thyroid Autoantibodies (ATAs).Journal of clinical medicine · 2022Article
- Association between sensitivity to thyroid hormone indices and the risk of osteoarthritis: an NHANES study.European journal of medical research · 2022Article
- Thyroid Function Alteration in Obesity and the Effect of Bariatric Surgery.Journal of clinical medicine · 2022Review
- Increased Central and Peripheral Thyroid Resistance Indices During the First Half of Gestation Were Associated With Lowered Risk of Gestational Diabetes-Analyses Based on Huizhou Birth Cohort in South China.Frontiers in endocrinology · 2022Article
- Higher maternal thyroid resistance indices were associated with increased neonatal thyroid-stimulating hormone- analyses based on the Huizhou mother-infant cohort.Frontiers in endocrinology · 2022Article
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
Abstract
Endocrine abnormalities are common in obesity, including altered thyroid function. The altered thyroid function of obesity may be due to a mild acquired resistance to the thyroid hormone. The aim of this study was to investigate the effect of weight loss after bariatric surgery (BS) on resistance to thyroid hormones in patients with extreme obesity compared with a control group. We performed an observational study evaluating patients with extreme obesity who underwent BS. We included 106 patients (83 women) and 38 controls (24 women). The primary endpoint was the thyrotroph thyroxine resistance index (TT4RI) and thyroid stimulating hormone (TSH) index (TSHRI). The parameters were studied before and after surgery. TSHRI and TT4RI were higher in the obese patients than in the control group. TT4RI and TSHI decreased significantly over time after surgery, with this decrease being associated with the excessive body mass index (BMI) loss and C-reactive protein (CRP). In extreme obesity, BS promotes a significant decrease in the increased TT4RI and TSHI. This decrease of TT4RI and TSHI is progressive over time after BS and significantly associated with excess BMI lost and CRP. Extreme obesity is characterized by a mild reversible central resistance to thyroid hormones.
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