Evidence map›Paper›PMID 32012925›Full record

ReviewInternational journal of molecular sciences2020

Alpha-1 Antitrypsin-A Target for MicroRNA-Based Therapeutic Development for Cystic Fibrosis.

Alison M D Hunt, Arlene M A Glasgow, Hilary Humphreys, Catherine M Greene

Open access · goldAbstract readReview
In one paragraph

Review in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.4field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 16 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Review
  6. Article
  7. Review
  8. Serum-Based Proteomics Profiling in Adult Patients with Cystic Fibrosis.International journal of molecular sciences · 2020
    Article
  9. Editorial: Special Issue on "Therapeutic Approaches for Cystic Fibrosis".International journal of molecular sciences · 2020
    Article
  10. Immunomodulation in Cystic Fibrosis: Why and How?International journal of molecular sciences · 2020
    Review
  11. A rare mutation on alpha-1 antitrypsin deficit and lung fibrosis: case report.Sarcoidosis, vasculitis, and diffuse lung diseases : official journal of WASOG · 2020
    Article
  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Alison M D HuntDepartment of Clinical Microbiology, Royal College of Surgeons in Ireland, Dublin 9, Ireland.
Arlene M A GlasgowDepartment of Clinical Microbiology, Royal College of Surgeons in Ireland, Dublin 9, Ireland.ORCID 0000-0001-8331-7668
Hilary HumphreysDepartment of Clinical Microbiology, Royal College of Surgeons in Ireland, Dublin 9, Ireland.
Catherine M GreeneDepartment of Clinical Microbiology, Royal College of Surgeons in Ireland, Dublin 9, Ireland.ORCID 0000-0003-2549-2569
Royal College of Surgeons in Ireland · IE

Funding

Alpha-1 Foundation Postdoctoral Fellowship 2019Horizon 2020 MSCA-IF 707771 GENDER-CFVertex Pharmaceuticals VIA Award 2018
6 · The paper itself

Abstract

Cystic fibrosis (CF) is an autosomal recessive genetic disorder arising from mutations to the cystic fibrosis transmembrane conductance regulator (

Indexed as

alpha 1-AntitrypsinAntagomirsCystic FibrosisCystic Fibrosis Transmembrane Conductance RegulatorHumansLeukocyte ElastaseMicroRNAsMolecular Targeted TherapyUp-Regulationalpha 1-AntitrypsinAntagomirsCFTR protein, humanCystic Fibrosis Transmembrane Conductance RegulatorELANE protein, humanLeukocyte ElastaseMicroRNAsSERPINA1 protein, humanalpha-1 antitrypsinantiproteasescystic fibrosismicroRNAneutrophil elastase

Identifiers

PMID32012925
PMCPMC7037267
OpenAlexW3003625606

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.