Evidence map›Paper›PMID 32012831›Full record

ArticleToxins2020

The Toxicological Intersection between Allergen and Toxin: A Structural Comparison of the Cat Dander Allergenic Protein Fel d1 and the Slow Loris Brachial Gland Secretion Protein.

Holger Scheib, K Anne-Isola Nekaris, Johanna Rode-Margono, Lotten Ragnarsson, Kate Baumann, James S Dobson, Wirdateti Wirdateti, Amanda Nouwens, Vincent Nijman, Paolo Martelli and 4 more

Open access · goldAbstract read
In one paragraph

Article in Toxins, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.4field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 19 citations in OpenAlex.

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  11. Hello, kitty: could cat allergy be a form of intoxication?The journal of venomous animals and toxins including tropical diseases · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 4 institutions in 4 countries.

Holger ScheibVenom Evolution Lab: School of Biological Sciences, University of Queensland, St Lucia, Qld 4072, Australia.
K Anne-Isola NekarisNocturnal Primate Research Group, Department of Social Sciences, Oxford Brookes University, Oxford OX3 0BP, UK.
Johanna Rode-MargonoNocturnal Primate Research Group, Department of Social Sciences, Oxford Brookes University, Oxford OX3 0BP, UK.
Lotten RagnarssonInstitute for Molecular Biosciences, University of Queensland, St Lucia, QLD 4072, Australia.
Kate BaumannVenom Evolution Lab: School of Biological Sciences, University of Queensland, St Lucia, Qld 4072, Australia.
James S DobsonVenom Evolution Lab: School of Biological Sciences, University of Queensland, St Lucia, Qld 4072, Australia.
Wirdateti WirdatetiResearch Center for Biology-LIPI, Jakarta-Bogor, Cibinong 16911, Indonesia.
Amanda NouwensSchool of Chemistry and Molecular Biosciences, University of Queensland, St Lucia, Qld 4072, Australia.
Vincent NijmanNocturnal Primate Research Group, Department of Social Sciences, Oxford Brookes University, Oxford OX3 0BP, UK.
Paolo MartelliVeterinary Department: Ocean Park, Hong Kong, China.
Rui MaInstitute of Translational Medicine, Faculty of Health Sciences, University of Macau, Avenida de Universidade, Taipa, Macau SAR, China.
Richard J LewisInstitute for Molecular Biosciences, University of Queensland, St Lucia, QLD 4072, Australia.
Hang Fai KwokInstitute of Translational Medicine, Faculty of Health Sciences, University of Macau, Avenida de Universidade, Taipa, Macau SAR, China.
Bryan Grieg FryVenom Evolution Lab: School of Biological Sciences, University of Queensland, St Lucia, Qld 4072, Australia.
The University of Queensland · AUOxford Brookes University · GBUniversity of Macau · MOIndonesian Institute of Sciences · ID

Funding

Australian Research Council DP190100304
6 · The paper itself

Abstract

Slow lorises are enigmatic animal that represent the only venomous primate lineage. Their defensive secretions have received little attention. In this study we determined the full length sequence of the protein secreted by their unique brachial glands. The full length sequences displayed homology to the main allergenic protein present in cat dander. We thus compared the molecular features of the slow loris brachial gland protein and the cat dander allergen protein, showing remarkable similarities between them. Thus we postulate that allergenic proteins play a role in the slow loris defensive arsenal. These results shed light on these neglected, novel animals.

Indexed as

AllergensCatsGlycoproteinsLorisidaeToxins, BiologicalAmino Acid SequenceAnimalsBase SequenceDanderModels, MolecularSequence Homology, Amino AcidAllergensFel d 1 protein, Felis domesticusGlycoproteinsToxins, Biologicalallergendanderevolutionprimatevenom

Identifiers

PMID32012831
PMCPMC7076782
OpenAlexW3003738186

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.