Evidence map›Paper›PMID 32012798›Full record

ArticleInternational journal of molecular sciences2020

Reciprocal Regulatory Interaction between TRPV1 and Kinin B1 Receptor in a Rat Neuropathic Pain Model.

Veronica Cernit, Jacques Sénécal, Rahmeh Othman, Réjean Couture

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 1 pooled it
2.0field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 1 synthesis or guideline pooled it, 27 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Supercritical COPharmaceutics · 2026
    Article
  4. Article
  5. Article
  6. Review
  7. Review
  8. Article
  9. TRPV1: The key bridge in neuroimmune interactions.Journal of intensive medicine · 2024
    Review
  10. Kinin BScientific reports · 2023
    Article
  11. Kinin BPharmaceutics · 2023
    Article
  12. Article
  13. Article
  14. Article
  15. Review
  16. Article
  17. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Veronica CernitDepartment of Pharmacology and Physiology, Faculty of Medicine, Université de Montréal, Montréal, QC H3C 3J7, Canada.
Jacques SénécalDepartment of Pharmacology and Physiology, Faculty of Medicine, Université de Montréal, Montréal, QC H3C 3J7, Canada.
Rahmeh OthmanDepartment of Pharmacology and Physiology, Faculty of Medicine, Université de Montréal, Montréal, QC H3C 3J7, Canada.
Réjean CoutureDepartment of Pharmacology and Physiology, Faculty of Medicine, Université de Montréal, Montréal, QC H3C 3J7, Canada.
Université de Montréal · CA

Funding

CIHR MOP-119329
6 · The paper itself

Abstract

Kinins are mediators of pain and inflammation and evidence suggests that the inducible kinin B1 receptor (B1R) is involved in neuropathic pain (NP). This study investigates whether B1R and TRPV1 are colocalized on nociceptors and/or astrocytes to enable regulatory interaction either directly or through the cytokine pathway (IL-1β, TNF-α) in NP. Sprague Dawley rats were subjected to unilateral partial sciatic nerve ligation (PSNL) and treated from 14 to 21 days post-PSNL with antagonists of B1R (SSR240612, 10 mg·kg

Indexed as

AnimalsAstrocytesBradykinin B1 Receptor AntagonistsDisease Models, AnimalGanglia, SpinalNeuralgiaNociceptive PainRatsReceptor, Bradykinin B1RNA, MessengerSpinal CordTRPV Cation ChannelsBradykinin B1 Receptor AntagonistsReceptor, Bradykinin B1RNA, MessengerTrpv1 protein, ratTRPV Cation ChannelsallodyniaastrocytesB1 receptorbradykinincytokinesdorsal root ganglionhyperalgesiasensory fibersspinal cordTRPV1

Identifiers

PMID32012798
PMCPMC7037982
OpenAlexW3000993351

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.