Evidence map›Paper›PMID 32012743›Full record

ArticleDiagnostics (Basel, Switzerland)2020

Circulating Anti-Sorting Nexins 16 Antibodies as an Emerging Biomarker of Coronary Artery Disease in Patients with Obstructive Sleep Apnea.

Yusuke Katsumata, Jiro Terada, Takuma Matsumura, Ken Koshikawa, Seiichiro Sakao, Go Tomiyoshi, Natsuko Shinmen, Rika Nakamura, Hideyuki Kuroda, Kengo Nagashima and 6 more

Abstract read
In one paragraph

Article in Diagnostics (Basel, Switzerland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Role of sleep disorders in patients with cardiovascular disease: A systematic review.International journal of cardiology. Cardiovascular risk and prevention · 2024
    Review
  3. Article
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Yusuke KatsumataDepartment of Respirology, Graduate School of Medicine, Chiba University, Chiba 260-8670, Chiba, Japan.
Jiro TeradaDepartment of Respirology, Graduate School of Medicine, Chiba University, Chiba 260-8670, Chiba, Japan.
Takuma MatsumuraDepartment of Respirology, Graduate School of Medicine, Chiba University, Chiba 260-8670, Chiba, Japan.
Ken KoshikawaDepartment of Respirology, Graduate School of Medicine, Chiba University, Chiba 260-8670, Chiba, Japan.
Seiichiro SakaoDepartment of Respirology, Graduate School of Medicine, Chiba University, Chiba 260-8670, Chiba, Japan.
Go TomiyoshiFujikura Kasei Co.,Ltd., Minato-ku, Tokyo 105-0011, Japan.
Natsuko ShinmenFujikura Kasei Co.,Ltd., Minato-ku, Tokyo 105-0011, Japan.
Rika NakamuraFujikura Kasei Co.,Ltd., Minato-ku, Tokyo 105-0011, Japan.
Hideyuki KurodaFujikura Kasei Co.,Ltd., Minato-ku, Tokyo 105-0011, Japan.
Kengo NagashimaResearch Center for Medical and Health Data Science, The Institute of Statistical Mathematics, Tokyo 190-8562, Japan.
Yoshio KobayashiDepartment of Cardiovascular Medicine, Graduate School of Medicine, Chiba University, Chiba 260-8670, Japan.
Eiichi KobayashiDepartment of Neurological Surgery, Graduate School of Medicine, Chiba University, Chiba 260-8670, Japan.
Yasuo IwadateDepartment of Neurological Surgery, Graduate School of Medicine, Chiba University, Chiba 260-8670, Japan.
Xiao-Meng ZhangDepartment of Biochemistry and Genetics, Graduate School of Medicine, Chiba University, Chiba 260-8670, Japan.
Takaki HiwasaDepartment of Neurological Surgery, Graduate School of Medicine, Chiba University, Chiba 260-8670, Japan.
Koichiro TatsumiDepartment of Respirology, Graduate School of Medicine, Chiba University, Chiba 260-8670, Chiba, Japan.

Funding

Japan Society for the Promotion of Science 19K08596
6 · The paper itself

Abstract

Biomarkers are not available for monitoring the onset and progression of coronary artery disease (CAD) in patients with obstructive sleep apnea (OSA), a major risk factor for arteriosclerotic cardiovascular diseases. This study aimed to test for correlation between circulating anti-Sorting Nexins 16 antibody (SNX16-Ab) levels, CAD history and clinical parameters of patients with OSA. Sixty-four healthy donors, 82 adults with OSA, and 96 with acute coronary syndrome (ACS) were studied. Serum samples were collected at diagnostic polysomnography in the OSA group or at the disease onset in the ACS group. Serum SNX16-Ab levels were measured by amplified luminescence proximity homogeneous assay (AlphaLISA), and correlation between SNX16-Ab levels and clinical parameters was analyzed. SNX16-Ab levels and apnea-hypopnea index (AHI) were weakly correlated. Additionally, logistic regression analyses of OSA group identified that elevated SNX16-Ab level associated with the history of CAD. Circulating SNX16-Ab could increase during CAD pathogenesis in patients with OSA. Further prospective studies are required to prove the predictive potential of SNX16-Ab level in CAD onset of patients with OSA.

Indexed as

atherosclerosisautoantibodybiomarkercoronary arteryobstructive sleep apnea

Identifiers

PMID32012743
PMCPMC7168932

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.