Evidence map›Paper›PMID 32012719›Full record

ArticleCancers2020

Deciphering the Molecular Mechanism of Spontaneous Senescence in Primary Epithelial Ovarian Cancer Cells.

Martyna Pakuła, Ewa Mały, Paweł Uruski, Anna Witucka, Małgorzata Bogucka, Natalia Jaroszewska, Nicoletta Makowska, Arkadiusz Niklas, Rafał Moszyński, Stefan Sajdak and 3 more

Erratum issuedOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancers, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
2.7field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 29 citations in OpenAlex.

  1. Review
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  9. Eosinophilic Cells as a Distinct Morphological Feature inDiagnostics (Basel, Switzerland) · 2025
    Article
  10. Review
  11. Review
  12. Cellular senescence: Neither irreversible nor reversible.The Journal of experimental medicine · 2024
    Article
  13. Review
  14. Article
  15. Cellular senescence in cancer: clinical detection and prognostic implications.Journal of experimental & clinical cancer research : CR · 2022
    Review
  16. Review
  17. Review
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors at 1 institution in 1 country.

Martyna PakułaDepartment of Hypertensiology, Angiology and Internal Medicine, Poznan University of Medical Sciences, Długa 1/2 Str., 61-848 Poznan, Poland.
Ewa MałyPoznan University of Medical Sciences Core Facility, Rokietnicka 8 Str., 60-806 Poznan, Poland.
Paweł UruskiDepartment of Hypertensiology, Angiology and Internal Medicine, Poznan University of Medical Sciences, Długa 1/2 Str., 61-848 Poznan, Poland.
Anna WituckaDepartment of Hypertensiology, Angiology and Internal Medicine, Poznan University of Medical Sciences, Długa 1/2 Str., 61-848 Poznan, Poland.
Małgorzata BoguckaPoznan University of Medical Sciences Core Facility, Rokietnicka 8 Str., 60-806 Poznan, Poland.
Natalia JaroszewskaPoznan University of Medical Sciences Core Facility, Rokietnicka 8 Str., 60-806 Poznan, Poland.
Nicoletta MakowskaPoznan University of Medical Sciences Core Facility, Rokietnicka 8 Str., 60-806 Poznan, Poland.
Arkadiusz NiklasDepartment of Hypertensiology, Angiology and Internal Medicine, Poznan University of Medical Sciences, Długa 1/2 Str., 61-848 Poznan, Poland.
Rafał MoszyńskiDivision of Gynecological Surgery, Poznan University of Medical Sciences, Polna 33 Str, 60-535 Poznan, Poland.
Stefan SajdakDivision of Gynecological Surgery, Poznan University of Medical Sciences, Polna 33 Str, 60-535 Poznan, Poland.
Andrzej TykarskiDepartment of Hypertensiology, Angiology and Internal Medicine, Poznan University of Medical Sciences, Długa 1/2 Str., 61-848 Poznan, Poland.
Justyna Mikuła-PietrasikDepartment of Hypertensiology, Angiology and Internal Medicine, Poznan University of Medical Sciences, Długa 1/2 Str., 61-848 Poznan, Poland.
Krzysztof KsiążekDepartment of Hypertensiology, Angiology and Internal Medicine, Poznan University of Medical Sciences, Długa 1/2 Str., 61-848 Poznan, Poland.
Poznan University of Medical Sciences · PL

Funding

Narodowe Centrum Nauki 2017/25/B/NZ3/00122
6 · The paper itself

Abstract

Spontaneous senescence of cancer cells remains a puzzling and poorly understood phenomenon. Here we comprehensively characterize this process in primary epithelial ovarian cancer cells (pEOCs). Analysis of tumors from ovarian cancer patients showed an abundance of senescent cells in vivo. Further, serially passaged pEOCs become senescent after a few divisions. These senescent cultures display trace proliferation, high expression of senescence biomarkers (SA--Gal, -H2A.X), growth-arrest in the G

Indexed as

aging biomarkerscancer biologycellular senescenceepithelial ovarian canceroxidative stress

Identifiers

PMID32012719
PMCPMC7072138
OpenAlexW3000984298

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.