Evidence map›Paper›PMID 32012716›Full record

ArticleMicroorganisms2020

Prenatal and Peripartum Exposure to Antibiotics and Cesarean Section Delivery Are Associated with Differences in Diversity and Composition of the Infant Meconium Microbiome.

Wendy S W Wong, Priya Sabu, Varsha Deopujari, Shira Levy, Ankit A Shah, Nicole Clemency, Marina Provenzano, Reem Saadoon, Akhil Munagala, Robin Baker and 6 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Microorganisms, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed, 2 pooled it
9.5field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 2 syntheses or guidelines pooled it, 64 citations in OpenAlex.

  1. Global Microbiome: Core and Unique Signatures Across Diverse Populations.International journal of molecular sciences · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 8 institutions in 1 country.

Wendy S W WongInova Translational Medicine Institute, Falls Church, Inova Fairfax Hospital, Falls Church, VA 22042, USA.
Priya SabuSchool of Medicine, Virginia Commonwealth University, Richmond, VA 23298, USA.
Varsha DeopujariInova Translational Medicine Institute, Falls Church, Inova Fairfax Hospital, Falls Church, VA 22042, USA.
Shira LevyInova Translational Medicine Institute, Falls Church, Inova Fairfax Hospital, Falls Church, VA 22042, USA.
Ankit A ShahDivision of Maternal Fetal Medicine, Department of Ob/Gyn, Inova Fairfax Hospital, Falls Church, VA 22042, USA.
Nicole ClemencyInova Translational Medicine Institute, Falls Church, Inova Fairfax Hospital, Falls Church, VA 22042, USA.
Marina ProvenzanoInova Translational Medicine Institute, Falls Church, Inova Fairfax Hospital, Falls Church, VA 22042, USA.
Reem SaadoonInova Translational Medicine Institute, Falls Church, Inova Fairfax Hospital, Falls Church, VA 22042, USA.
Akhil MunagalaInova Translational Medicine Institute, Falls Church, Inova Fairfax Hospital, Falls Church, VA 22042, USA.
Robin BakerFairfax Neonatal Associates, Falls Church, VA 22042, USA.
Rajiv BavejaFairfax Neonatal Associates, Falls Church, VA 22042, USA.
Noel T MuellerDepartment of Epidemiology, Johns Hopkins School of Public Health, Baltimore, MD 21205, USA.
Maria Gloria Dominguez-BelloDepartment of Biochemistry and Microbiology, Rutgers University, New Brunswick, NJ 08901, USA.
Kathi HuddlestonInova Translational Medicine Institute, Falls Church, Inova Fairfax Hospital, Falls Church, VA 22042, USA.
John E NiederhuberInova Translational Medicine Institute, Falls Church, Inova Fairfax Hospital, Falls Church, VA 22042, USA.
Suchitra K HouriganInova Children's Hospital, Inova Fairfax Hospital, Falls Church, VA 22042, USA.
Inova Fairfax Hospital · USFairfax Neonatal Associates · USGeorge Mason University · USJohns Hopkins Medicine · USJohns Hopkins University · USRutgers, The State University of New Jersey · USVirginia Cancer Specialists · USVirginia Commonwealth University · US

Funding

The Effects of Diet on the Gut Microbiome and Short Chain Fatty AcidsK01HL141589 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI MUELLER, NOEL T · 2018 to 2022
$845k
The contribution of antibiotic exposure in the prenatal, peripartum and infancy period to intestinal microbiome perturbations and association with early childhood obesity.K23HD099240 · NICHD · INOVA HEALTH CARE SERVICES · PI HOURIGAN, SUCHITRA · 2019 to 2021
$476k
NHLBI NIH HHS K01 HL141589NICHD NIH HHS K23 HD099240
6 · The paper itself

Abstract

The meconium microbiome may provide insight into intrauterine and peripartum exposures and the very earliest intestinal pioneering microbes. Prenatal antibiotics have been associated with later obesity in children, which is thought to be driven by microbiome dependent mechanisms. However, there is little data regarding associations of prenatal or peripartum antibiotic exposure, with or without cesarean section (CS), with the features of the meconium microbiome. In this study, 16S ribosomal RNA gene sequencing was performed on bacterial DNA of meconium samples from 105 infants in a birth cohort study. After multivariable adjustment, delivery mode (

Indexed as

antibioticsdelivery modeinfantmicrobiomeneonatepediatrics

Identifiers

PMID32012716
PMCPMC7074690
OpenAlexW3002469760

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.