ArticleObesity (Silver Spring, Md.)2020
Maternal Birth Weight and BMI Mediate the Transgenerational Effect of Grandmaternal BMI on Grandchild's Birth Weight.
Article in Obesity (Silver Spring, Md.), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
8 citing papers in PubMed.
- Article
- Exploring the multilevel determinants of low birth weight in Bangladesh: Understanding implications for targeted public health interventions.PLOS global public health · 2026Article
- Grandmaternal body mass index in early pregnancy and risk of grandoffspring stillbirth: a nationwide, 3-generation cohort study.American journal of epidemiology · 2024Article
- The role of epigenetics in multi-generational transmission of asthma: An NIAID workshop report-based narrative review.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2022Review
- Article
- Exploring the evidence for epigenetic regulation of environmental influences on child health across generations.Communications biology · 2021Review
- The Impact of Early-Life Exposures on Women's Reproductive Health in Adulthood.Current epidemiology reports · 2021Review
- Transgenerational Studies: How Do We Investigate Multigenerational Effects?Obesity (Silver Spring, Md.) · 2020Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
objectiveThe aims of this study are to examine the potential association between grandmaternal BMI and grandchild's birth weight (BW) and whether maternal BW and BMI mediate this association.
methodsData of 209 grandmother-mother pairs and 355 grandchildren from the Isle of Wight birth cohort in the UK were analyzed using path analysis.
resultsAn indirect effect of grandmaternal BMI on increasing grandchild's BW was mediated by maternal BW and BMI at age 18 years (indirect effects: β = 2.3 g/unit increase in grandmaternal BMI via maternal BW and β = 4.4 g via maternal BMI; P = 0.04). These two mediating effects of maternal BW and BMI confounded one another. Grandmaternal smoking during pregnancy had an indirect effect on decreasing grandchild's BW, dependent on maternal smoking during pregnancy and BW (indirect effects: β = -36.1 g compared with nonsmoking grandmothers via maternal smoking during pregnancy and β = -27.2 g via maternal BW; P = 0.005). Neither direct effect between grandmaternal BMI and grandchild's BW nor that between grandmaternal smoking during pregnancy and grandchild's BW was statistically significant.
conclusionsLarger grandmaternal BMI indirectly increased grandchild's BW via maternal BW and BMI. Grandmaternal smoking during pregnancy indirectly reduced grandchild's BW via maternal smoking during pregnancy and BW.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.