Evidence map›Paper›PMID 32012419›Full record

ReviewGenes, brain, and behavior2020

Prospects for finding the mechanisms of sex differences in addiction with human and model organism genetic analysis.

Udita Datta, Sarah E Schoenrock, Jason A Bubier, Molly A Bogue, James D Jentsch, Ryan W Logan, Lisa M Tarantino, Elissa J Chesler

Open access · hybridAbstract readReview
In one paragraph

Review in Genes, brain, and behavior, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
2.0field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 19 citations in OpenAlex.

  1. Article
  2. Article
  3. Helping Women Suffering from Drug Addiction: Needs, Barriers, and Challenges.International journal of environmental research and public health · 2022
    Article
  4. Article
  5. Article
  6. A Gender Perspective of Addictive Disorders.Current addiction reports · 2021
    Review
  7. Article
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Udita DattaCenter for Systems Neurogenetics of Addiction, The Jackson Laboratory, Bar Harbor, Maine.
Sarah E SchoenrockCenter for Systems Neurogenetics of Addiction, Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.ORCID 0000-0001-7345-444X
Jason A BubierCenter for Systems Neurogenetics of Addiction, The Jackson Laboratory, Bar Harbor, Maine.ORCID 0000-0001-5013-1234
Molly A BogueCenter for Systems Neurogenetics of Addiction, The Jackson Laboratory, Bar Harbor, Maine.
James D JentschCenter for Systems Neurogenetics of Addiction, Psychology, State University of New York at Binghamton, Binghamton, New York.
Ryan W LoganCenter for Systems Neurogenetics of Addiction, Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.
Lisa M TarantinoCenter for Systems Neurogenetics of Addiction, Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.ORCID 0000-0001-9984-2600
Elissa J CheslerCenter for Systems Neurogenetics of Addiction, The Jackson Laboratory, Bar Harbor, Maine.ORCID 0000-0002-5642-5062
Jackson Laboratory · USUniversity of North Carolina at Chapel Hill · USBinghamton University · USUniversity of Pittsburgh · US

Funding

Social Anxiety, Stress and Ethanol Sensitivity in Adolescence and AdulthoodP50AA017823 · NIAAA · UPSTATE MEDICAL UNIVERSITY · PI J. DAVID JENTSCH · 2009 to 2026
$30.5M
Project 5: Circadian RhythmsP50DA039841 · NIDA · JACKSON LABORATORY · PI Lisa M Tarantino · 2016 to 2026
$26.2M
Mouse Phenome ProjectR01DA028420 · NIDA · JACKSON LABORATORY · PI Elissa J Chesler · 2010 to 2026
$9.5M
Discovery of Addiction-Related Genes with Advanced Mouse ResourcesR01DA037927 · NIDA · JACKSON LABORATORY · PI CHESLER, ELISSA J · 2015 to 2025
$8.1M
Genetic Control of Addiction by Host and MicrobiomeU01DA043809 · NIDA · JACKSON LABORATORY · PI BUBIER, JASON A, ZHOU, YANJIAO · 2018 to 2022
$4.0M
Genetic pathways for impulsivity and drug reinforcement: DNA and transcriptome variation in miceU01DA041602 · NIDA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ESKIN, ELEAZAR, JENTSCH, J. DAVID · 2017 to 2021
$3.2M
NIAAA NIH HHS P50 AA017823NIDA NIH HHS P50 DA039841NIDA NIH HHS R01 DA028420NIDA NIH HHS R01 DA037927NIDA NIH HHS U01 DA041602NIDA NIH HHS U01 DA043809
6 · The paper itself

Abstract

Despite substantial evidence for sex differences in addiction epidemiology, addiction-relevant behaviors and associated neurobiological phenomena, the mechanisms and implications of these differences remain unknown. Genetic analysis in model organism is a potentially powerful and effective means of discovering the mechanisms that underlie sex differences in addiction. Human genetic studies are beginning to show precise risk variants that influence the mechanisms of addiction but typically lack sufficient power or neurobiological mechanistic access, particularly for the discovery of the mechanisms that underlie sex differences. Our thesis in this review is that genetic variation in model organisms are a promising approach that can complement these investigations to show the biological mechanisms that underlie sex differences in addiction.

Indexed as

Disease Models, AnimalGenotypeSex CharacteristicsAnimalsFemaleGenome-Wide Association StudyHumansMaleSubstance-Related Disordersaddictionaddiction predictiveanimal modelsbehaviorgeneticsgenomicsheritabilityneurobiologicalsex differencessubstance use disorder

Identifiers

PMID32012419
PMCPMC7060801
OpenAlexW3004075208

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.