Evidence map›Paper›PMID 32012257›Full record

Trial reportFamily process2020

A Randomized Comparison of Two Psychosocial Interventions on Family Functioning in Adolescents with Bipolar Disorder.

Lisa A O'Donnell, Marc J Weintraub, Alissa J Ellis, David A Axelson, Robert A Kowatch, Christopher D Schneck, David J Miklowitz

Open access · greenAbstract readRandomized Controlled Trial
In one paragraph

Trial report in Family process, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
2.1field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it, 25 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Trial
  4. Article
  5. Virtual reality, social intelligence, mirror neurons, and bipolar spectrum: a new perspective.Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999) · 2025
    Article
  6. Review
  7. Article
  8. Article
  9. Review
  10. Review
  11. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Lisa A O'DonnellSchool of Social Work, Wayne State University, Detroit, MI.ORCID 0000-0001-6649-2894
Marc J WeintraubDepartment of Psychiatry, Semel Institute, University of California, Los Angeles, Los Angeles, CA.
Alissa J EllisDepartment of Psychiatry, Semel Institute, University of California, Los Angeles, Los Angeles, CA.
David A AxelsonThe Ohio State University College of Medicine, Columbus, OH.
Robert A KowatchThe Ohio State University College of Medicine, Columbus, OH.
Christopher D SchneckDepartment of Psychiatry, University of Colorado School of Medicine, Aurora, CO.
David J MiklowitzDepartment of Psychiatry, Semel Institute, University of California, Los Angeles, Los Angeles, CA.
University of California, Los Angeles · USThe Ohio State University · USUniversity of Colorado Denver · USWayne State University · US

Funding

Family-Focused Therapy for Individuals at High Clinical Risk for Psychosis: A Confirmatory Efficacy TrialR01MH123575 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI BEARDEN, CARRIE E, MIKLOWITZ, DAVID JAY · 2020 to 2023
$5.4M
1/2-Early Intervention for Youth at Risk for Bipolar DisorderR01MH093676 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI MIKLOWITZ, DAVID JAY · 2012 to 2016
$3.6M
Neurodevelopment and Psychosis in the 22q11.2 Copy Number VariantsR37MH085953 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI CARRIE E BEARDEN · 2023 to 2026
$2.9M
Family-Focused Treatment for Bipolar AdolescentsR01MH073817 · NIMH · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI AXELSON, DAVID A · 2006 to 2010
$1.7M
Family-Focused Treatment for Bipolar AdolescentsR01MH073871 · NIMH · UNIVERSITY OF COLORADO · PI MIKLOWITZ, DAVID JAY · 2006 to 2010
$1.7M
Family-Focused Treatment for Bipolar AdolescentsR01MH074033 · NIMH · CINCINNATI CHILDRENS HOSP MED CTR · PI KOWATCH, ROBERT ANTHONY · 2006 to 2010
$1.3M
Technology-Enhanced Family-Focused Treatment for Adolescents at High Risk for Mood DisordersR34MH117200 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI AREVIAN, ARMEN C, MIKLOWITZ, DAVID JAY · 2018 to 2020
$933k
Family-Focused Therapy as Early Treatment for Youth at Risk for Bipolar DisorderR34MH077856 · NIMH · UNIVERSITY OF COLORADO · PI MIKLOWITZ, DAVID JAY · 2007 to 2009
$638k
NIMH NIH HHS R01 MH073817NIMH NIH HHS R01 MH073871NIMH NIH HHS R01 MH074033NIMH NIH HHS R01 MH093676NIMH NIH HHS R01 MH123575NIMH NIH HHS R34 MH077856NIMH NIH HHS R34 MH117200NIMH NIH HHS R37 MH085953
6 · The paper itself

Abstract

Impairments in family functioning are associated with more severe depressive and manic symptoms, earlier recurrences, and more suicidal behaviors in early-onset bipolar disorder. This study examined whether family-focused treatment for adolescents (FFT-A) with BD I or II disorder led to greater increases in family cohesion and adaptability and decreases in conflict over 2 years compared to a briefer psychoeducational treatment (enhanced care, EC). Participants were 144 adolescents (mean age: 15.6 ± 1.4 years) with BD I or II with a mood episode in the previous 3 months. Adolescents and parents were randomized to either FFT-A (21 sessions) or EC (three sessions). Patients received guideline-based pharmacotherapy throughout the 2-year study. Trajectories of adolescent- and parent-rated family cohesion, adaptability, and conflict were analyzed over 2 years. FFT-A had greater effects on adolescent-rated family cohesion compared to EC over 2 years. Participants in FFT-A and EC reported similar improvements in family conflict across the 2 years. In the FFT-A group, low-conflict families had greater adolescent-rated family cohesion throughout the study compared to high-conflict families. High-conflict families in both treatment groups tended to show larger reductions in conflict over 2 years than low-conflict families. Family psychoeducation and skills training may improve family cohesion in the early stages of BD. Measuring levels of family conflict at the start of treatment may inform treatment responsiveness among those receiving FFT-A.

Indexed as

AdolescentAdultAffectBipolar DisorderFamily ConflictFamily RelationsFamily TherapyFemaleHumansMaleParentsPsychosocial InterventionPsychotherapy, BriefTreatment OutcomeAdaptabilityAdolescenceBipolar DisorderCohesionFamily-Focused TherapyFamily FunctioningMood Disorder

Identifiers

PMID32012257
PMCPMC7282964
OpenAlexW3004455759

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.