ArticleInternational journal of cancer2020
Adult weight change and premenopausal breast cancer risk: A prospective pooled analysis of data from 628,463 women.
Article in International journal of cancer, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 3 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 3 syntheses or guidelines pooled it, 41 citations in OpenAlex.
- Visceral fat area as a prognostic biomarker in gastric cancer: a systematic review and meta-analysis of survival outcomes.Frontiers in oncology · 2025Pooled it
- How does weight gain since the age of 18 years affect breast cancer risk in later life? A meta-analysis.Breast cancer research : BCR · 2024Pooled it
- Risk factors for breast cancer in women: an update review.Medical oncology (Northwood, London, England) · 2022Pooled it
- Low Frequency of Pathogenic Variants in BRCA1 Exons 11/20 and BRCA2 Exon 11 Suggests Divergent Mutational Hotspots in Sudanese Breast Cancer Patients: A Case-Control Study.Breast cancer : basic and clinical research · 2026Article
- Metabolomic signatures of hypocaloric dietary interventions associate with breast cancer risk in the Nurses' Health Study II.medRxiv : the preprint server for health sciences · 2025Article
- Anthropometry and the Risk of Breast Cancer in Moroccan Women: A Large Multicentric Case-Control Study.Current oncology (Toronto, Ont.) · 2025Article
- Hormone-associated dietary patterns and premenopausal breast cancer risk.Breast cancer research and treatment · 2025Article
- Central and peripheral adiposity and premenopausal breast cancer risk: a pooled analysis of 440,179 women.Breast cancer research : BCR · 2025Article
- The impact of reproductive factors on breast tumor and normal-adjacent tissue immune profile from menarche to menopause.Carcinogenesis · 2025Article
- [Factors Influencing Progression on the Ultrasound BI-RADS Categories: An Analysis Based on a Breast Cancer Screening Cohort].Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition · 2024Article
- Weight gain after 35 years of age is associated with increased breast cancer risk: findings from a large prospective cohort study.Cancer biology & medicine · 2024Article
- International Pooled Analysis of Leisure-Time Physical Activity and Premenopausal Breast Cancer in Women From 19 Cohorts.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2024Article
- Associations of height, body mass index, and weight gain with breast cancer risk in carriers of a pathogenic variant in BRCA1 or BRCA2: the BRCA1 and BRCA2 Cohort Consortium.Breast cancer research : BCR · 2023Article
- The timing of adiposity and changes in the life course on the risk of cancer.Cancer metastasis reviews · 2022Review
- Long-term weight change and risk of breast cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC) study.International journal of epidemiology · 2022Article
- Cancer Progress and Priorities: Breast Cancer.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2021Review
- Article
- The Association Between Periodontal Disease and Breast Cancer in a Prospective Cohort Study.Cancer prevention research (Philadelphia, Pa.) · 2020Article
Corrections and comments
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Authors and funding
43 authors at 20 institutions in 11 countries.
Funding
Abstract
Early-adulthood body size is strongly inversely associated with risk of premenopausal breast cancer. It is unclear whether subsequent changes in weight affect risk. We pooled individual-level data from 17 prospective studies to investigate the association of weight change with premenopausal breast cancer risk, considering strata of initial weight, timing of weight change, other breast cancer risk factors and breast cancer subtype. Hazard ratios (HR) and 95% confidence intervals (CI) were obtained using Cox regression. Among 628,463 women, 10,886 were diagnosed with breast cancer before menopause. Models adjusted for initial weight at ages 18-24 years and other breast cancer risk factors showed that weight gain from ages 18-24 to 35-44 or to 45-54 years was inversely associated with breast cancer overall (e.g., HR per 5 kg to ages 45-54: 0.96, 95% CI: 0.95-0.98) and with oestrogen-receptor(ER)-positive breast cancer (HR per 5 kg to ages 45-54: 0.96, 95% CI: 0.94-0.98). Weight gain from ages 25-34 was inversely associated with ER-positive breast cancer only and weight gain from ages 35-44 was not associated with risk. None of these weight gains were associated with ER-negative breast cancer. Weight loss was not consistently associated with overall or ER-specific risk after adjusting for initial weight. Weight increase from early-adulthood to ages 45-54 years is associated with a reduced premenopausal breast cancer risk independently of early-adulthood weight. Biological explanations are needed to account for these two separate factors.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.