Trial reportPloS one2020
Apical periodontitis healing and postoperative pain following endodontic treatment with a reciprocating single-file, single-cone approach: A randomized controlled pragmatic clinical trial.
Trial report in PloS one, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 21 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Outcomes of primary root canal therapy: An updated systematic review of longitudinal clinical studies published between 2003 and 2020.International endodontic journal · 2022Pooled it
- Pooled it
- Comparison of post-operative pain prevalence after single visit endodontic treatment with two NiTi rotary files - a randomized clinical trial.Scientific reports · 2025Trial
- Postoperative Pain Following Single-Visit Nonsurgical Retreatment Using Minimally Invasive Rotary vs. Reciprocating Nickel-Titanium File Systems: A Two-Arm Parallel Randomized Clinical Trial.Pain research & management · 2025Trial
- Effect of different obturation techniques on treatment results in single-visit non-surgical endodontic retreatment: randomized controlled clinical study.BMC oral health · 2024Trial
- Impact XP-endo finisher on the 1-year follow-up success of posterior root canal treatments: a randomized clinical trial.Clinical oral investigations · 2023Trial
- Prospective comparative study on postoperative pain after single-visit root canal treatment using rotary and reciprocating kinematics.Odontology · 2026Article
- Three-Year Apical Outcomes in Teeth with Apical Periodontitis Following Primary Endodontic Treatment or Nonsurgical Retreatment: A Retrospective Clinical Study.Journal of clinical medicine · 2026Article
- Postoperative Pain After Root Canal Filling with Different Bioceramic Endodontic Sealers: A Double-Blind Randomized Clinical Pilot Trial.Healthcare (Basel, Switzerland) · 2026Article
- Investigation of the effect of low torque and speed values on postoperative pain after root canal treatment: a randomised clinical trial.BMC oral health · 2025Article
- Using fractal analysis to assess periapical bone formation after endodontic treatment: A systematic review and meta-analysis.Imaging science in dentistry · 2025Review
- Root canal therapy combined with endoscopic sinus surgery for odontogenic sinusitis: Efficacy comparison in a cohort study.World journal of clinical cases · 2025Article
- Impact of using single-file reciprocating system on the quality of root canal treatment treated by undergraduate students.The Saudi dental journal · 2024Article
- Postoperative pain in oncological patients subjected to nonsurgical root canal treatment: a prospective case-control study.Clinical oral investigations · 2024Article
- Pain Assessment in Oral Medicine through Its Different Dimensions: A Comprehensive Review.Dentistry journal · 2023Review
- Influence of the root canal filling technique on the success rate of primary endodontic treatments: a systematic review.Restorative dentistry & endodontics · 2022Review
- Present status and future directions: Canal shaping.International endodontic journal · 2022Review
- Management of apical periodontitis using WaveOne gold reciprocating files, single-cone endodontic approach: A case series author.Annals of medicine and surgery (2012) · 2021Article
- Effects of Both Fiber Post/Core Resin Construction System and Root Canal Sealer on the Material Interface in Deep Areas of Root Canal.Materials (Basel, Switzerland) · 2021Article
- Analysis of Cosmetic Effect of Nanocomposite Resin on Anterior Teeth.Computational and mathematical methods in medicine · 2021Observational
Corrections and comments
- Erratum issued
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This trial assessed post-operative pain and healing of apical periodontitis following endodontic therapy with a reciprocating system compared to a crown-down technique with hand files and lateral compaction filling. One-hundred and twenty nonvital anterior teeth with apical periodontitis were randomly treated using either a reciprocating single file followed by matching-taper single-cone filling or a hand file and lateral compaction filling. Postoperative pain was assessed during the 7 days after the treatment, using a visual analogue scale and a verbal rating scale. Apical healing was assessed using the periapical index score after a 12-month follow-up. The hypothesis tested was that both protocols were equivalent and present similar effectiveness in healing periapical lesions. Data were analyzed through two one-sided tests, t-tests, as well as Mann-Whitney and Chi-squared tests (α = 0.05). Logistic regression was used to investigate the association of clinical and demographic factors with the success of treatment. Regardless of the assessment time, no difference in incidence (38%-43% at first 24h), intensity of postoperative pain, and incidence of flare-up (≈ 3%) was observed between the two endodontic protocols. Both protocols resulted in a similar healing rate of apical periodontitis. After 12 months, the success rate ranged from 73% to 78% and the difference between the treatments fell within the pre-established equivalence margin (-0.1; -0.41 to 0.2). Endodontic treatment combining a reciprocating single file with matching-taper single cone showed similar clinical effectiveness to the treatment using hand-file instrumentation and the lateral compaction filling.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.