Evidence map›Paper›PMID 32011809›Full record

Trial reportBJS open2020

Randomized clinical trial of the effect of intraoperative humidified carbon dioxide insufflation in open laparotomy for colorectal resection.

J Y Cheong, B Chami, G M Fong, X S Wang, A Keshava, C J Young, P Witting

Registry-linked trialOpen access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in BJS open, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02975947 (Effect of Intraoperative Humidified CO2 Insufflation in Open Laparotomy Colorectal Surgery Patients), which is not on this map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.5field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02975947 nacompletednot on this map

Effect of Intraoperative Humidified CO2 Insufflation in Open Laparotomy Colorectal Surgery Patients: a Randomized Controlled Trial

TypeinterventionalSponsorConcord Repatriation General HospitalRan2013 to 2016Enrolled40ConditionsPeritoneal Inflammation, Peritoneum, InjuryArmsHumidified, warmed CO2 insufflation of open peritoneum using Fisher & Paykel's HUMIGARD (Fisher & Paykel Healthcare Ltd, Auckland, New Zealand), Standard heating
3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 9 citations in OpenAlex.

  1. Surgical Humidification (HumiGardGlobal spine journal · 2026
    Article
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

J Y CheongColorectal Unit, Concord Repatriation General Hospital, Concord Clinical School, Concord, New South Wales, Australia.ORCID 0000-0002-1600-7632
B ChamiDepartment of Pathology, Sydney Medical School, University of Sydney, Sydney, New South Wales, Australia.
G M FongDepartment of Pathology, Sydney Medical School, University of Sydney, Sydney, New South Wales, Australia.
X S WangDepartment of Pathology, Sydney Medical School, University of Sydney, Sydney, New South Wales, Australia.
A KeshavaColorectal Unit, Concord Repatriation General Hospital, Concord Clinical School, Concord, New South Wales, Australia.
C J YoungColorectal Unit, Concord Repatriation General Hospital, Concord Clinical School, Concord, New South Wales, Australia.
P WittingDepartment of Pathology, Sydney Medical School, University of Sydney, Sydney, New South Wales, Australia.
The University of Sydney · AUConcord Repatriation General Hospital · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAnimal studies have shown that peritoneal injury can be minimized by insufflating the abdominal cavity with warm humidified carbon dioxide gas.

methodsA single-blind RCT was performed at a tertiary colorectal unit. Inclusion criteria were patient aged 18 years and over undergoing open elective surgery. The intervention group received warmed (37°C), humidified (98 per cent relative humidity) carbon dioxide (WHCO

resultsOf 40 patients enrolled, 20 in the WHCO

conclusionThe use of warmed, humidified carbon dioxide appears to reduce some markers related to peritoneal oxidative damage during laparotomy. No difference was observed in clinical outcomes, but the study was underpowered for analysis of surgical results. Registration number: NCT02975947 ( www.ClinicalTrials.gov/).

Indexed as

Body TemperatureHumidityAgedCarbon DioxideCytokinesElective Surgical ProceduresFemaleHumansInsufflationIntestine, LargeIntraoperative ComplicationsLaparotomyMaleMiddle AgedPeritoneal DiseasesPostoperative PainCarbon DioxideCytokines

Identifiers

PMID32011809
PMCPMC6996635
OpenAlexW2984984789

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.