Evidence map›Paper›PMID 32011780›Full record

ArticleJournal of clinical laboratory analysis2020

Function and regulation annotation of up-regulated long non-coding RNA LINC01234 in gastric cancer.

Yinyin Zhu, Cong Luo, Arshad Ali Korakkandan, Yislam Hadi Ahmed Fatma, Yang Tao, Tianfei Yi, Shiyun Hu, Qi Liao

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of clinical laboratory analysis, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.6field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 8 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Yinyin ZhuDepartment of Preventative Medicine, Zhejiang Provincial Key Laboratory of Pathological and Physiological Technology, Medical School of Ningbo University, Ningbo, China.
Cong LuoDepartment of Abdominal Oncology, Zhejiang Cancer Hospital, Hangzhou, China.
Arshad Ali KorakkandanDepartment of Preventative Medicine, Zhejiang Provincial Key Laboratory of Pathological and Physiological Technology, Medical School of Ningbo University, Ningbo, China.
Yislam Hadi Ahmed FatmaDepartment of Preventative Medicine, Zhejiang Provincial Key Laboratory of Pathological and Physiological Technology, Medical School of Ningbo University, Ningbo, China.
Yang TaoNingbo Yinzhou People's Hospital, Ningbo, China.
Tianfei YiDepartment of Preventative Medicine, Zhejiang Provincial Key Laboratory of Pathological and Physiological Technology, Medical School of Ningbo University, Ningbo, China.
Shiyun HuDepartment of Preventative Medicine, Zhejiang Provincial Key Laboratory of Pathological and Physiological Technology, Medical School of Ningbo University, Ningbo, China.
Qi LiaoDepartment of Preventative Medicine, Zhejiang Provincial Key Laboratory of Pathological and Physiological Technology, Medical School of Ningbo University, Ningbo, China.ORCID https://orcid.org/0000-0001-6796-104X
Ningbo University · CNZhejiang Cancer Hospital · CN

Funding

K.C.Wong Magna Fund in Ningbo UniversityNational Natural Science Foundation of China 31970630the Natural Science Foundation of Ningbo 2016A610121the Natural Science Foundation of Ningbo 2017A610154The Scientific Innovation Team Project of Ningbo 2016C51001The Scientific Innovation Team Project of Ningbo 2017C110019Zhejiang Key Laboratory of Pathophysiology 201812
6 · The paper itself

Abstract

backgroundAccumulated evidences indicate that long non-coding RNAs (lncRNAs) participate in many biological mechanisms. Moreover, it acts as an essential regulator in various human diseases such as gastric cancer (GC). Nevertheless, the comprehensive regulatory roles and clinical significance of most lncRNAs in GC are not fully understood.

methodsIn this research, our aim was to investigate the underlying mechanism of lncRNA LINC01234 in GC. Firstly, the usage of qRT-PCR helped to establish expression pattern of LINC01234 in GC tissues. Following this, appropriate statistical tests were applied to analyze the relation between expression level and clinicopathological factors. Ultimately, potential functions and regulatory network of LINC01234 were concluded via GSEA and a series of bioinformatics tools or databases, respectively.

resultsConsequently, at the end of research we found LINC01234 is up-regulated in GC tissues in comparison with adjacent normal tissues. Furthermore, its expression level is correlated with differentiation of patients with GC. It is also important to highlight bioinformatics analysis revealed that LINC01234 is involved in cancer-associated pathways such as cell cycle and mismatch repair. Also, regulatory network of LINC01234 presented a probability in the involvement of tumorigenesis through regulating cancer-associated genes.

conclusionOverall, our results suggested that LINC01234 may play a crucial role in GC.

Indexed as

AdenocarcinomaAgedBiomarkers, TumorFemaleGene Expression Regulation, NeoplasticGene Regulatory NetworksHumansMaleMicroRNAsMiddle AgedRNA, Long NoncodingStomach NeoplasmsUp-RegulationBiomarkers, TumorMicroRNAsRNA, Long Noncodinggastric cancerLINC01234long non-coding RNAregulatory network

Identifiers

PMID32011780
PMCPMC7246363
OpenAlexW3004510514

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.