SynthesisMedicine2020
Better outcomes are associated with cementless fixation in primary total knee arthroplasty in young patients: A systematic review and meta-analysis of randomized controlled trials.
Synthesis in Medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05840887 (Knee Osteotomy Associated With Allograft Meniscus Transplantation in Patients With Altered Mechanical Axis, Meniscectomy Outcomes, and Osteoarthritis), which is not on this map. Cited by 21 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Knee Osteotomy Associated With Allograft Meniscus Transplantation in Patients With Altered Mechanical Axis, Meniscectomy Outcomes, and Osteoarthritis: Clinical, Biomechanical, and Biological Evaluation
Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Long-term effects of cemented and cementless fixations of total knee arthroplasty: a meta-analysis and systematic review of randomized controlled trials.Journal of orthopaedic surgery and research · 2021Pooled it
- Early Results of Unrestricted Kinematic Alignment in Cementless Total Knee Arthroplasty.Arthroplasty today · 2026Article
- Cementless versus hybrid fixation in primary total knee arthroplasty: a propensity score-matched analysis of mid-term outcomes.Arthroplasty (London, England) · 2026Article
- [Good recovery of leisure activities and sport after primary implantation of cementless knee arthroplasty after 5 years : A retrospective study].Orthopadie (Heidelberg, Germany) · 2026Article
- Patient selection and management for successful cementless total knee arthroplasty.Knee surgery & related research · 2026Review
- Global trends in fixation methods for primary total knee arthroplasty: An international registry-based analysis and review of outcomes.Journal of orthopaedics · 2025Article
- What Are the Game Changers in Total Knee Arthroplasty? A Narrative Review.Journal of personalized medicine · 2025Review
- Advancements in Total Knee Arthroplasty over the Last Two Decades.Journal of clinical medicine · 2025Review
- Fixation in total knee arthroplasty: are cemented implants still mandatory in younger and obese patients?European journal of orthopaedic surgery & traumatology : orthopedie traumatologie · 2025Review
- Clinical outcomes and radiolucent line analysis in cementless mobile-bearing total knee arthroplasty: a prospective multicentre study in Japan.Scientific reports · 2024Article
- Cemented vs. Cementless Fixation in Primary Knee Replacement: A Narrative Review.Materials (Basel, Switzerland) · 2024Review
- No Blood Loss Increase in Cementless vs. Cemented Fixation Following Bilateral Total Knee Arthroplasty: A Propensity Score Matching Study.Medicina (Kaunas, Lithuania) · 2023Article
- A TEN-YEAR FOLLOW-UP AFTER CEMENTLESS TOTAL KNEE ARTHROPLASTY IN COUNTY GENERAL HOSPITAL.Acta clinica Croatica · 2023Article
- Uncemented Tibial Fixation Has Comparable Prognostic Outcomes and Safety Versus Cemented Fixation in Cruciate-Retaining Total Knee Arthroplasty: A Meta-Analysis of Randomized Controlled Trials.Journal of clinical medicine · 2023Review
- No component loosening of a cementless deep dish rotating platform knee at a 5-year follow-up.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2023Observational
- The mid-term survival of cemented, uncemented, and hybrid fixation of the ACS mobile bearing total knee arthroplasty.Indian journal of orthopaedics · 2022Article
- Highlighting the advantages and benefits of cementless total knee arthroplasty (Review).Experimental and therapeutic medicine · 2022Review
- Migration of the femoral component and clinical outcomes after total knee replacement: a narrative review.Musculoskeletal surgery · 2021Review
- Cemented versus uncemented total knee arthroplasty in younger patients: A protocol of retrospective cohort trial.Medicine · 2020Article
- Prior knee arthroscopy effects on subsequent total knee arthroplasty: A protocol of match-controlled study.Medicine · 2020Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe use of cemented and cementless fixations in primary total knee arthroplasty (TKA) in young patients is controversial. Previous reviews predominantly relied on data from retrospective studies. This systematic review and meta-analysis of randomized controlled trials (RCTs) evaluated the optimal fixation mode in TKA for young patients.
methodsThe PubMed, Embase, Medline, Web of Science, and full Cochrane Library electronic databases were searched from inception to July 2018. The outcome measurements consisted of functional outcomes (Knee Society Score [KSS], range of motion [ROM]), radiolucent lines, aseptic loosening, total complications, and reoperation rate. Study data were pooled using a random-effects model.
resultsSix RCTs were included in the systematic review and meta-analysis. The mean follow-up period was 12 years (range, 2-16.6 years). Cementless TKA was associated with higher KSS-function (P < .0001), higher KSS-pain (P = .005), better ROM recovery (P = .01), and fewer radiolucent lines (<1 mm) (P = .04) compared with cemented TKA. No significant intergroup differences were observed for KSS-knee, total complications, aseptic loosening, or reoperation rate. These results based on a random-effects model were unchanged by sensitivity analysis assumptions.
conclusionCementless TKA was substantially superior to cemented TKA in young patients. Although the complication and survival rates were similar between groups, better clinical outcomes were obtained with cementless fixation. Further well-designed studies with long follow-up durations are necessary to confirm our findings.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.