ReviewThe Journal of clinical investigation2020
Opportunities and challenges in using real-world data for health care.
Review in The Journal of clinical investigation, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06018753 (Umbrella Study for Analysis of Data Related to Patients With Cancer), which is not on this map. Cited by 102 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Umbrella Study for Analysis of Data Related to Patients With Cancer
Who cites it
102 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Effectiveness of tofacitinib in patients with ulcerative colitis: an updated systematic review and meta-analysis of real-world studies.BMJ open gastroenterology · 2024Pooled it
- Peripheral Nerve Stimulation for Chronic Neuropathic Pain: A Health Technology Assessment.Ontario health technology assessment series · 2024Pooled it
- Systematic review and meta-analysis: real-world data rates of deep remission with anti-TNFα in inflammatory bowel disease.BMC gastroenterology · 2021Pooled it
- Real-World Imaging Data: Opportunities and Challenges.JMIR medical informatics · 2026Article
- Pathways to Real World Evidence From the Real World of School-Based Physical Fitness Testing (SB-PFT).Learning health systems · 2026Article
- Full-Body AI Agent: A Perspective on Multi-Scale Collaborative AI for Systemic Biology and Precision Medicine.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
- Long COVID Persistence and Surveillance Gaps Across 58 US Hospitals.JAMA network open · 2026Article
- Predicting intrauterine vacuum-induced postpartum hemorrhage-control device treatment success.Pregnancy (Hoboken, N.J.) · 2026Article
- Recent Advances in AI and GenAI for Health Informatics.Healthcare (Basel, Switzerland) · 2026Review
- Assessment of the integrity of real-time electronic health record data used in clinical research.PloS one · 2026Article
- Linking clinical trial data with real-world data for enhanced clinical evidence generation: methodological considerations and recommendations.Frontiers in pharmacology · 2026Review
- Review
- Article
- Real-world first-line outcomes of alectinib and brigatinib in anaplastic lymphoma kinase-positive non-small cell lung cancer: a nationwide South Korean cohort study using the health insurance review and assessment data.Translational lung cancer research · 2025Article
- Beyond Comparing Machine Learning and Logistic Regression in Clinical Prediction Modelling: Shifting from Model Debate to Data Quality.Journal of medical Internet research · 2025Article
- Large Language Models for Automating Clinical Trial Criteria Conversion to Observational Medical Outcomes Partnership Common Data Model Queries: Validation and Evaluation Study.JMIR medical informatics · 2025Article
- The Oregis Dashboard: Web-based Ophthalmic Research Benchmarking in Germany.Klinische Monatsblatter fur Augenheilkunde · 2025Article
- Leveraging Synthetic Data to Facilitate Research: A Collaborative Model for Analyzing Sensitive National Cancer Registry Data in England.Therapeutic innovation & regulatory science · 2025Article
- A Multi-Layered Framework for Modeling Human Biology: From Basic AI Agents to a Full-Body AI Agent.ArXiv · 2025Article
- Artificial intelligence-enhanced pain management: the NXTSTIM EcoAI platform.Pain management · 2025Review
42 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Real-world data (RWD) continue to emerge as a new source of clinical evidence. Although the best-known use case of RWD has been in drug regulation, RWD are being generated and used by many other parties, including biopharmaceutical companies, payors, clinical researchers, providers, and patients. In this Review, we describe 21 potential uses for RWD across the spectrum of health care. We also discuss important challenges and limitations relevant to the translation of these data into evidence.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.