ArticleeLife2020
RNA polymerase mutations cause cephalosporin resistance in clinical
Open access · goldAbstract read
In one paragraph
Article in eLife, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed
4.8field-weighted citation impact, top 4% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
32 citing papers in PubMed, 48 citations in OpenAlex.
- Mutations in RNA polymerase that drive the emergence of antibiotic resistance.Current opinion in microbiology · 2026Review
- Put your money where your mouth is: surveillance of antibiotic resistance within the commensalMicrobiology spectrum · 2026Article
- Deciphering the pangenome of the shellfish pathogenMicrobial genomics · 2026Article
- Put your money where your mouth is: Surveillance of antibiotic resistance within the commensalbioRxiv : the preprint server for biology · 2026Article
- Article
- Evolution of beta-lactam resistance causes fitness reductions and several cases of collateral sensitivities in the human pathogenAntimicrobial agents and chemotherapy · 2025Article
- CommensalAnnual review of microbiology · 2025Review
- Characterization of Penicillin-Non-Susceptible, Multidrug-Resistant Streptococcus agalactiae Using Whole-Genome Sequencing.Current microbiology · 2025Article
- A mutation in RNA polymerase imparts resistance to β-lactams by preventing dysregulation of amino acid and nucleotide metabolism.Cell reports · 2025Article
- Genetic identification of mutations and MLST types associated with decreased susceptibility to ceftriaxone inFrontiers in microbiology · 2025Article
- The novel 2024 WHO Neisseria gonorrhoeae reference strains for global quality assurance of laboratory investigations and superseded WHO N. gonorrhoeae reference strains-phenotypic, genetic and reference genome characterization.The Journal of antimicrobial chemotherapy · 2024Article
- Integrating bacterial molecular genetics with chemical biology for renewed antibacterial drug discovery.The Biochemical journal · 2024Review
- Rolling the evolutionary dice:Microbiology spectrum · 2024Article
- Progressive Sub-MIC Exposure ofAntibiotics (Basel, Switzerland) · 2023Article
- The whole-cell proteome shows the characteristics of macrolides-resistant Bordetella pertussis in China linked to the biofilm formation.Archives of microbiology · 2023Article
- Machine learning models for Neisseria gonorrhoeae antimicrobial susceptibility tests.Annals of the New York Academy of Sciences · 2023Review
- CanB is a metabolic mediator of antibiotic resistance in Neisseria gonorrhoeae.Nature microbiology · 2023Article
- Molecular Mechanisms of Drug Resistance and Epidemiology of Multidrug-Resistant Variants ofInternational journal of molecular sciences · 2022Review
- Convergent Evolution of Antibiotic Tolerance in Patients with Persistent Methicillin-Resistant Staphylococcus aureus Bacteremia.Infection and immunity · 2022Article
- Bioinformatics tools used for whole-genome sequencing analysis of Neisseria gonorrhoeae: a literature review.Briefings in functional genomics · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 5 institutions in 2 countries.
Samantha G PalaceDepartment of Immunology and Infectious Diseases, Harvard T. H. Chan School of Public Health, Boston, United States.ORCID 0000-0002-7849-8078
Yi WangDepartment of Immunology and Infectious Diseases, Harvard T. H. Chan School of Public Health, Boston, United States.
Daniel Hf RubinDepartment of Immunology and Infectious Diseases, Harvard T. H. Chan School of Public Health, Boston, United States.
Michael A WelshDepartment of Microbiology, Harvard Medical School, Boston, United States.ORCID 0000-0001-8268-6285
Tatum D MortimerDepartment of Immunology and Infectious Diseases, Harvard T. H. Chan School of Public Health, Boston, United States.
Kevin ColePublic Health England, Royal Sussex County Hospital, Brighton, United Kingdom.
David W EyreBig Data Institute, University of Oxford, Oxford, United Kingdom.
Suzanne WalkerDepartment of Microbiology, Harvard Medical School, Boston, United States.
Yonatan H GradDepartment of Immunology and Infectious Diseases, Harvard T. H. Chan School of Public Health, Boston, United States.ORCID 0000-0001-5646-1314
Harvard University · USBrigham and Women's Hospital · USCenter for Disease Dynamics, Economics & Policy · USOpen Data Institute · GBRoyal Sussex County Hospital · GB
Funding
Medical Scientist Training ProgramT32GM007753 · NIGMS · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI WALENSKY, LOREN DAVID · 1985 to 2021
$50.0MMechanism and Inhibition of Enzymes that Assemble Bacterial Cell WallR01GM076710 · NIGMS · HARVARD MEDICAL SCHOOL · PI WALKER, SUZANNE · 2007 to 2019
$5.9MDiscovery and characterization of new bacterial cell wall targets and inhibitors to treat resistant infectionsR01AI148752 · NIAID · HARVARD MEDICAL SCHOOL · PI Daniel Kahne, Suzanne Walker · 2020 to 2026
$5.5MGenomics approaches to elucidating pathways to antibiotic resistance in Neisseria gonorrhoeaeR01AI132606 · NIAID · HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH · PI Yonatan H Grad · 2017 to 2026
$3.8MBiochemical characterization of LMW PBPS with novel transpeptidase activityF32GM123579 · NIGMS · HARVARD MEDICAL SCHOOL · PI WELSH, MICHAEL AVERY · 2017 to 2019
$130kNIAID NIH HHS R01 AI132606NIAID NIH HHS R01 AI148752NIGMS NIH HHS F32 GM123579NIGMS NIH HHS R01 GM076710NIGMS NIH HHS T32 GM007753
Abstract
Increasing
Indexed as
Mutation, MissenseAnti-Bacterial AgentsBacterial ProteinsCephalosporin ResistanceCephalosporinsDNA-Directed RNA PolymerasesGenes, BacterialMicrobial Sensitivity TestsNeisseria gonorrhoeaeAnti-Bacterial AgentsBacterial ProteinsCephalosporinsDNA-Directed RNA Polymerasesantibiotic resistanceantimicrobial resistancecephalosporinsgonorrheainfectious diseasemicrobiologyNeisseria gonorrhoeae
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.