Evidence map›Paper›PMID 32011232›Full record

ArticleeLife2020

Accelerated viral dynamics in bat cell lines, with implications for zoonotic emergence.

Cara E Brook, Mike Boots, Kartik Chandran, Andrew P Dobson, Christian Drosten, Andrea L Graham, Bryan T Grenfell, Marcel A Müller, Melinda Ng, Lin-Fa Wang and 1 more

Open access · goldAbstract read
In one paragraph

Article in eLife, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 82 papers.

0numbers the graph read from it
0cells of the map it votes in
82citing papers in PubMed
2.6field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

82 citing papers in PubMed, 130 citations in OpenAlex.

  1. Review
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  7. A NovelViruses · 2025
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22 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 9 institutions in 5 countries.

Cara E BrookDepartment of Integrative Biology, University of California, Berkeley, Berkeley, United States.ORCID 0000-0003-4276-073X
Mike BootsDepartment of Integrative Biology, University of California, Berkeley, Berkeley, United States.
Kartik ChandranDepartment of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, United States.ORCID 0000-0003-0232-7077
Andrew P DobsonDepartment of Ecology and Evolutionary Biology, Princeton University, Princeton, United States.
Christian DrostenInstitute of Virology, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany.
Andrea L GrahamDepartment of Ecology and Evolutionary Biology, Princeton University, Princeton, United States.ORCID 0000-0002-6580-2755
Bryan T GrenfellDepartment of Ecology and Evolutionary Biology, Princeton University, Princeton, United States.
Marcel A MüllerInstitute of Virology, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany.ORCID 0000-0003-2242-5117
Melinda NgDepartment of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, United States.
Lin-Fa WangEmerging Infectious Diseases Program, Duke-National University of Singapore Medical School, Singapore, Singapore.ORCID 0000-0003-2752-0535
Anieke van LeeuwenDepartment of Ecology and Evolutionary Biology, Princeton University, Princeton, United States.ORCID 0000-0003-1987-1458
Albert Einstein College of Medicine · USPrinceton University · USHumboldt-Universität zu Berlin · DENational Institutes of Health · USNational Kidney Foundation Singapore · SGNational University of Singapore · SGSechenov University · RUUniversity of California, Berkeley · USUtrecht University · NL

Funding

Scientific and Technical Computing CoreP2CHD047879 · NICHD · PRINCETON UNIVERSITY · PI SALGANIK, MATTHEW J. · 2014 to 2018
$2.0M
Host-virus interactions in the control of filovirus entryR01AI134824 · NIAID · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI CHANDRAN, KARTIK · 2018 to 2021
$1.9M
Investigating seasonal drivers of viral zoonoses from Madagascar fruit batsR01AI129822 · NIAID · PASTEUR INSTITUTE FROM MADAGASCAR · PI DUSSART, PHILIPPE · 2017 to 2021
$674k
Adolph C. and Mary Sprague Miller Institute for Basic Research in Science, University of California Berkeley Postdoctoral FellowshipBundesministerium für Bildung und Forschung RAPID #01KI1723ADARPA PREEMPT Program - Cooperative Agreement no. D18AC00031Deutsche Forschungsgemeinschaft DR 772/10-2European Union Horizon Grant 2020 #653316German Federal Ministry of Education and Research RAPID #01KI1723AHorizon 2020 #653316National Science Foundation Graduate Research FellowshipNIAID NIH HHS R01 AI129822NIAID NIH HHS R01 AI134824NICHD NIH HHS P2C HD047879NIH HHS 1R01AI129822-01NIH HHS R01-AI134824Singapore National Research Foundation NRF2012NRF-CRP001-056Singapore National Research Foundation NRF2016NRF-NSFC002-013Singapore National Research Foundation Grant NRF2012NRF-CRP001-056Singapore National Research Foundation Grant NRF2016NRF-NSFC002-013
6 · The paper itself

Abstract

Bats host virulent zoonotic viruses without experiencing disease. A mechanistic understanding of the impact of bats' virus hosting capacities, including uniquely constitutive immune pathways, on cellular-scale viral dynamics is needed to elucidate zoonotic emergence. We carried out virus infectivity assays on bat cell lines expressing induced and constitutive immune phenotypes, then developed a theoretical model of our

Indexed as

AnimalsCell LineChiropteraDisease ReservoirsHost Microbial InteractionsHumansImmunity, CellularKineticsModels, BiologicalPhenotypeRisk AssessmentVirulenceVirus DiseasesVirusesZoonosesbatChiropteraecologyepidemiologyglobal healthinnate immunityinterferonwithin-host model

Identifiers

PMID32011232
PMCPMC7064339
OpenAlexW3004978876

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.