Evidence map›Paper›PMID 32011025›Full record

ReviewJournal of clinical periodontology2020

Periodontitis and cardiovascular diseases: Consensus report.

Mariano Sanz, Alvaro Marco Del Castillo, Søren Jepsen, Jose R Gonzalez-Juanatey, Francesco D'Aiuto, Philippe Bouchard, Iain Chapple, Thomas Dietrich, Israel Gotsman, Filippo Graziani and 11 more

Registry-linked trialOpen access · bronzeAbstract readReviewConsensus Statement
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of clinical periodontology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07077122 (Evaluation of the Systemic Burden of Non-surgical Periodontal Therapy), which is not on this map. Cited by 807 papers, 14 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
807citing papers in PubMed, 14 pooled it
110.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07077122 narecruitingnot on this mapstarted 2025, after this paper: background citation

Evaluation of the Systemic Burden of Non-surgical Periodontal Therapy: A Randomized Clinical Trial on Five Different Treatment Protocols

TypeinterventionalSponsorNational and Kapodistrian University of AthensRan2025 to 2027Enrolled75ConditionsPeriodontitisArmsScaling and Root Planing, antibiotic prophylaxis, 810nm Diode Laser, Air Polishing
3 · Its place in the literature

Who cites it

807 citing papers in PubMed, 14 syntheses or guidelines pooled it, 1,359 citations in OpenAlex.

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747 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors at 18 institutions in 12 countries.

Mariano SanzDepartment of Dental Clinical Specialties, ETEP Research Group, Faculty of Odontology, University Complutense of Madrid, Madrid, Spain.ORCID 0000-0002-6293-5755
Alvaro Marco Del CastilloCardiology Department, Hospital Universitario Ramon y Cajal, Madrid, Spain.
Søren JepsenDepartment of Periodontology, Operative and Preventive Dentistry, University of Bonn, Bonn, Germany.ORCID 0000-0002-4160-5837
Jose R Gonzalez-JuanateyCardiology Department, University Hospital, IDIS, CIBERCV, Univerity of Santiago de Compostela, Santiago de Compostela, Spain.
Francesco D'AiutoDepartment of Periodontology, Eastman Dental Institute and Hospital, University College London, London, UK.
Philippe BouchardU.F.R. d'odontologie, Université Paris Diderot, Hôpital Rothschild AP-HP, Paris, France.
Iain ChappleSchool of Dentistry, Institute of Clinical Sciences, College of Medical & Dental Sciences, The University of Birmingham, Birmingham, UK.
Thomas DietrichSchool of Dentistry, Institute of Clinical Sciences, College of Medical & Dental Sciences, The University of Birmingham, Birmingham, UK.
Israel GotsmanHeart Institute, Hadassah University Hospital, Jerusalem, Israel.
Filippo GrazianiDepartment of Surgical, Medical and Molecular Pathology and Critical Care Medicine, University of Pisa, Pisa, Italy.ORCID 0000-0001-8780-7306
David HerreraDepartment of Dental Clinical Specialties, ETEP Research Group, Faculty of Odontology, University Complutense of Madrid, Madrid, Spain.ORCID 0000-0002-5554-2777
Bruno LoosACTA University, Amsterdam, The Netherlands.ORCID 0000-0002-8794-552X
Phoebus MadianosDepartment of Periodontology, School of Dentistry, National and Kapodistrian University of Athens, Athens, Greece.ORCID 0000-0003-0935-5601
Jean-Baptiste MichelInserm Unit 1148, Laboratory for Translational CV Science, X. Bichat Hospital, Paris, France.
Pablo PerelWorld Heart Federation, Geneva, Switzerland.
Burkert PieskeDepartment of Internal Medicin & Cardiology, Charité Universitätsmedizin Berlin, Berlin, Germany.
Lior ShapiraDepartment of Periodontology, Hebrew University - Hadassah Faculty of Dental Medicine, Jerusalem, Israel.ORCID 0000-0001-9145-5155
Michael ShechterLeviev Heart Center, Chaim Sheba Medical Center, tel Hashomer and the Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv-Yafo, Israel.
Maurizio TonettiDepartment of Periodontology, Prince Philip Dental Hospital, The University of Hong Kong, Hong Kong, Hong Kong.ORCID 0000-0002-2743-0137
Charalambos Vlachopoulos1st Department of Cardiology, National and Kapodistrian University of Athens, Athens, Greece.
Gernot WimmerDepartment of Prosthetic Dentistry, School of Dental Medicine, Karl-Franzens University Graz, Graz, Austria.
Birmingham Dental Hospital · GBNational and Kapodistrian University of Athens · GRUniversidad Complutense de Madrid · ESAcademic Center for Dentistry Amsterdam · NLEastman Dental Hospital · GBGerman Centre for Cardiovascular Research · DEHadassah Academic College · ILHebrew University of Jerusalem · ILHospital Universitario Ramón y Cajal · ESInserm · FRLondon School of Hygiene & Tropical Medicine · GBPrince Philip Dental Hospital · CNTel Aviv University · ILUniversidade de Santiago de Compostela · ESUniversité Paris Cité · FRUniversity of Bonn · DEUniversity of Graz · ATUniversity of Pisa · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIn Europe cardiovascular disease (CVD) is responsible for 3.9 million deaths (45% of deaths), being ischaemic heart disease, stroke, hypertension (leading to heart failure) the major cause of these CVD related deaths. Periodontitis is also a chronic non-communicable disease (NCD) with a high prevalence, being severe periodontitis, affecting 11.2% of the world's population, the sixth most common human disease. MATERIAL AND

methodsThere is now a significant body of evidence to support independent associations between severe periodontitis and several NCDs, in particular CVD. In 2012 a joint workshop was held between the European Federation of Periodontology (EFP) and the American Academy of Periodontology to review the literature relating periodontitis and systemic diseases, including CVD. In the last five years important new scientific information has emerged providing important emerging evidence to support these associations RESULTS AND

conclusionsThe present review reports the proceedings of the workshop jointly organised by the EFP and the World Heart Federation (WHF), which has updated the existing epidemiological evidence for significant associations between periodontitis and CVD, the mechanistic links and the impact of periodontal therapy on cardiovascular and surrogate outcomes. This review has also focused on the potential risk and complications of periodontal therapy in patients on anti thrombotic therapy and has made recommendations for dentists, physicians and for patients visiting both the dental and medical practices.

Indexed as

Periodontal DiseasesCardiovascular DiseasesEuropeHumansPeriodonticsPeriodontitisanti thrombotic therapyatherosclerosisbateremiacardiovascular diseasechronic inflammationperiodontal therapyperiodontitis

Identifiers

PMID32011025
PMCPMC7027895
OpenAlexW2995886183

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.