ArticleMagnetic resonance in medicine2020
Optimizing SNR for multi-metabolite hyperpolarized carbon-13 MRI using a hybrid flip-angle scheme.
Article in Magnetic resonance in medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- A flexible MRF approach to improve kinetic rate estimation with bSSFP-based hyperpolarized [1-Magnetic resonance in medicine · 2025Article
- The human placenta project: Funded studies, imaging technologies, and future directions.Placenta · 2023Review
- Acquisition and quantification pipeline for in vivo hyperpolarizedMagnetic resonance in medicine · 2022Article
- Review
- Optimizing SNR for multi-metabolite hyperpolarized carbon-13 MRI using a hybrid flip-angle scheme.Magnetic resonance in medicine · 2020Article
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Authors and funding
4 authors.
Funding
Abstract
purposeTo improve the SNR of hyperpolarized carbon-13 MRI of [1-
methodsEach image acquisition in a time-resolved imaging experiment used a unique spectrally varying RF pulse shape for msVFA. Therefore, the flip angle for every acquisition was optimized for pyruvate and each of its metabolites to yield the highest SNR across the acquisition. Multispectral VFA was compared with a spectrally varying constant flip-angle excitation model through simulations and in vivo. A modified broadband chemical shift-encoded gradient-echo sequence was used for in vivo experiments on six pregnant guinea pigs. Regions of interest placed in the placentae, maternal liver, and maternal kidneys were used as areas for SNR measurement.
resultsIn vivo experiments showed significant increases in SNR for msVFA relative to constant flip angle of up to 250% for multiple metabolites.
conclusionHyperpolarized carbon-13 imaging with msVFA excitation produces improved SNR for all metabolites in organs of interest.
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