ReviewPrenatal diagnosis2020
The impact of tobacco chemicals and nicotine on placental development.
Review in Prenatal diagnosis, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 6 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
33 citing papers in PubMed, 6 syntheses or guidelines pooled it, 68 citations in OpenAlex.
- Birth outcomes following intrauterine exposure to electronic nicotine delivery systems: a systematic review and meta-analysis.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2026Pooled it
- Integrating Social and Clinical Determinants of Pre-Eclampsia: A Hierarchical Systematic Review and Conceptual Framework for Prevention.BJOG : an international journal of obstetrics and gynaecology · 2026Pooled it
- Vaping and Smoking in Pregnancy-A Meta-Analysis of Neurobehavioural Development in Prenatally Exposed Offspring.Acta paediatrica (Oslo, Norway : 1992) · 2025Pooled it
- Maternal smoking during pregnancy and risk of childhood-onset type 1 diabetes in offspring: A systematic review and meta-analysis.Biomolecules & biomedicine · 2025Pooled it
- The waterpipe smoking and human health: a systematic review and meta-analysis of 191 observational studies.Systematic reviews · 2025Pooled it
- Association between active tobacco use during pregnancy and infant respiratory health: a systematic review and meta-analysis.BMJ open · 2020Pooled it
- Nicotine Exposure During Gestation: From Placental Dysfunction to Long-Term Neurobehavioral Outcomes.Birth defects research · 2026Review
- Perinatal Redox Dysregulation in Gestational Tobacco Exposure: Compartment-Specific Composite Indices and Their Association with Birth Outcomes-A Prospective Cohort Study.Antioxidants (Basel, Switzerland) · 2026Article
- Biomarkers of Maternal and Neonatal Oxidative and Nitrosative Stress During Delivery: An Exploratory Pilot Study on Maternal-Neonatal Adaptation to Stress.Journal of clinical medicine · 2026Article
- Review
- Effect of Oxidative Stress on Extracellular Vesicles Secreted by Caruncular Epithelial Cells Isolated from Bovine Placenta During Pregnancy-Preliminary Results.Animals : an open access journal from MDPI · 2026Article
- Newborn metabolomic perturbations associated with prenatal tobacco smoke exposure and early birth.Communications medicine · 2026Article
- The Developmental Origins of Asthma and COPD.Annual review of physiology · 2026Review
- The association of parental use of new tobacco products and combustible cigarettes with nausea and vomiting in pregnancy: a cross-sectional study.Environmental health and preventive medicine · 2026Article
- Maternal Smoking During Pregnancy and Risk of Autism Spectrum Disorder in Offspring: A Systematic Review and Meta-Analysis.Journal of clinical medicine · 2025Review
- Targeted Analysis of Placental Steroid Hormones in Relation to Maternal Tobacco Smoke Exposure: Early Markers Relevant to DOHaD (Developmental Origins of Health and Disease).International journal of molecular sciences · 2025Article
- Investigating the Relationship Between Maternal Smoking During Pregnancy and Offspring Handedness: Extending the Proxy Gene-by-Environment Mendelian Randomization Study Design to Include Polygenic Risk Scores.Behavior genetics · 2025Article
- Machine learning-enhanced surface-enhanced spectroscopic detection of polycyclic aromatic hydrocarbons in the human placenta.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Interpretable machine learning for predicting placental abruption in early-onset preeclampsia: model development and evaluation.Frontiers in medicine · 2025Article
- Autoimmune Thyroid Disease and Pregnancy: The Interaction Between Genetics, Epigenetics and Environmental Factors.Journal of clinical medicine · 2024Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Despite decades of messages warning about the dangers of tobacco use in pregnancy, 10% to 15% of pregnant women continue to smoke. Furthermore, an increased popularity of electronic nicotine delivery systems (ENDS) over the past decade in women of childbearing age raises parallel concerns regarding the effects of vaporized nicotine use in pregnancy. While research using animal models which mimic tobacco smoke and nicotine exposure in pregnancy have largely replicated findings in humans, few studies focus directly on the effects of these exposures on the placenta. Because the placenta is a fetal derived tissue, and nicotine and other components of tobacco smoke are either processed by or transported directly through the placenta, such studies help us understand the risks of these exposures on the developing fetus. In this review, we summarize research on the placenta and placental-derived cells examining either tobacco smoke or nicotine exposure, including both histologic and subcellular (ie, epigenetic and molecular) modifications. Collectively, these studies reveal that tobacco and nicotine exposure are accompanied by some common and several unique molecular and epigenomic placental modifications. Consideration of the nature and sequelae of these molecular mediators of risk may help to better inform the public and more effectively curtail modifiable behavior.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.