ArticleSchizophrenia bulletin2020
Main Symptomatic Treatment Targets in Suspected and Early Psychosis: New Insights From Network Analysis.
Article in Schizophrenia bulletin, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 42 citations in OpenAlex.
- Developmental coupling between obsessive-compulsive symptoms and psychotic-like experiences in youth: a four-wave longitudinal study.Scientific reports · 2026Article
- Subjective language disturbances in young patients at ultra-high risk for psychosis (UHR): what relevance for clinical prognosis? A 2-year follow-up study.European archives of psychiatry and clinical neuroscience · 2026Article
- A subject-based association network defines new pediatric sleep apnea phenotypes with different odds of recovery after treatment.Computer methods and programs in biomedicine · 2026Article
- Static and dynamic intracerebral signal analysis reveals protective networks against seizures in drug-resistant focal epilepsy.Brain communications · 2026Article
- Exploring the interconnections between baseline symptoms in ultra-high risk youth who did and did not transition to psychosis over three years: A network analysis comparison.European psychiatry : the journal of the Association of European Psychiatrists · 2025Article
- Multimodal biological profiles of symptom-based subgroups in recent-onset psychosis.Research square · 2025Article
- Revealing differential psychotic symptoms in schizophrenia and bipolar I disorder by manifold learning and network analyses.Translational psychiatry · 2025Article
- Impacts of risk thresholds and age on clinical high risk for psychosis: a comparative network analysis.European archives of psychiatry and clinical neuroscience · 2025Article
- Three-year course of clinical high-risk symptoms for psychosis in the community: a latent class analysis.Epidemiology and psychiatric sciences · 2025Article
- Clinical utility of the at-risk for psychosis state beyond transition: A multidimensional network analysis.European child & adolescent psychiatry · 2025Article
- Distinct multimodal biological and functional profiles of symptom-based subgroups in recent-onset psychosis.Research square · 2024Article
- Language and communication rehabilitation in patients with schizophrenia: A narrative review.Heliyon · 2024Review
- A whole-brain neuromark resting-state fMRI analysis of first-episode and early psychosis: Evidence of aberrant cortical-subcortical-cerebellar functional circuitry.NeuroImage. Clinical · 2024Article
- Bridging the phenomenological gap between predictive basic-symptoms and attenuated positive symptoms: a cross-sectional network analysis.Schizophrenia (Heidelberg, Germany) · 2022Article
- Symptom Structure in Schizophrenia: Implications of Latent Variable Modeling vs Network Analysis.Schizophrenia bulletin · 2022Article
- Clinical high-risk criteria of psychosis in 8-17-year-old community subjects and inpatients not suspected of developing psychosis.World journal of psychiatry · 2022Article
- Using language in social media posts to study the network dynamics of depression longitudinally.Nature communications · 2022Article
- A network analysis of anxiety, depressive, and psychotic symptoms and functioning in children and adolescents at clinical high risk for psychosis.Frontiers in psychiatry · 2022Article
- Disentangling the symptoms of schizophrenia: Network analysis in acute phase patients and in patients with predominant negative symptoms.European psychiatry : the journal of the Association of European Psychiatrists · 2021Article
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Corrections and comments
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Authors and funding
10 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The early detection and intervention in psychoses prior to their first episode are presently based on the symptomatic ultra-high-risk and the basic symptom criteria. Current models of symptom development assume that basic symptoms develop first, followed by attenuated and, finally, frank psychotic symptoms, though interrelations of these symptoms are yet unknown. Therefore, we studied for the first time their interrelations using a network approach in 460 patients of an early detection service (mean age = 26.3 y, SD = 6.4; 65% male; n = 203 clinical high-risk [CHR], n = 153 first-episode psychosis, and n = 104 depression). Basic, attenuated, and frank psychotic symptoms were assessed using the Schizophrenia Proneness Instrument, Adult version (SPI-A), the Structured Interview for Psychosis-Risk Syndromes (SIPS), and the Positive And Negative Syndrome Scale (PANSS). Using the R package qgraph, network analysis of the altogether 86 symptoms revealed a single dense network of highly interrelated symptoms with 5 discernible symptom subgroups. Disorganized communication was the most central symptom, followed by delusions and hallucinations. In line with current models of symptom development, the network was distinguished by symptom severity running from SPI-A via SIPS to PANSS assessments. This suggests that positive symptoms developed from cognitive and perceptual disturbances included basic symptom criteria. Possibly conveying important insight for clinical practice, central symptoms, and symptoms "bridging" the association between symptom subgroups may be regarded as the main treatment targets, in order to prevent symptomatology from spreading or increasing across the whole network.
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