ArticleScience advances2020
Deficient histone H3 propionylation by BRPF1-KAT6 complexes in neurodevelopmental disorders and cancer.
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Article in Science advances, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 65 papers.
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65citing papers in PubMed
4.5field-weighted citation impact, top 4% of its field
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Who cites it
65 citing papers in PubMed, 101 citations in OpenAlex.
- Perinatal insults, genetic susceptibility, and the pathogenesis of neurodevelopmental disorders: from epigenetic remodeling to neural circuit dysfunction-a narrative review.Translational pediatrics · 2026Review
- Propionic acidemia as a framework for understanding the impact of disturbed propionyl-CoA on histone modifications.Biochemical Society transactions · 2026Review
- Aspirin-Derived Salicyl-CoA Drives Histone Lysine Salicylation Regulated by CBP and SIRT2.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Efficient and Fast Site-Directed Mutagenesis via Partially or Completely Overlapping Primer Pairs.Bio-protocol · 2026Article
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- Epigenetic programming by H3K23ac defines lineage fate of Meg3Nature cell biology · 2026Article
- Coming to light: the transcriptional regulatory roles of histone lysine crotonylation in health and disease.Cellular & molecular biology letters · 2026Review
- Lysine Propionylation as a Metabolically Coupled PTM: Mechanisms, Functional Consequences, and Therapeutic Potentials.International journal of molecular sciences · 2026Review
- Metabolic control of feto-placental development and pregnancy outcomes.Nature reviews. Endocrinology · 2026Review
- Biological Activity and Structural Biology of Current KAT6A Inhibitor Chemotypes.Journal of medicinal chemistry · 2026Article
- Article
- Epigenetic alterations in Myeloid Malignancies.Advances in experimental medicine and biology · 2026Review
- Seamless and Highly Efficient Site-directed Mutagenesis for Protein, RNA, and Plasmid Engineering.Current protocols · 2026Article
- Highly Efficient Site-Specific and Cassette Mutagenesis of Plasmids Harboring GC-Rich Sequences.Cells · 2025Article
- Post-translational acylation of proteins in cardiac hypertrophy.Nature reviews. Cardiology · 2025Review
- Lysine Acetyltransferase 6 in Health and Disease.MedComm · 2025Review
- Correlation between KAT6A and PD-L1 expression and role of KAT6A in colorectal cancer.World journal of gastrointestinal oncology · 2025Article
- KAT6A chimeras form a self-reinforcing epigenetic module with NURF and MLL/COMPASS to sustain AML.Genome biology · 2025Article
- FBRSL1 regulates the expression of chromatin regulators BRPF1 and KAT6A.Human genetics · 2025Article
- The Phenotypic and Genotypic Spectrum of BRPF1-Related Disorder: 29 New Patients and Literature Review.Clinical genetics · 2025Review
5 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
32 authors at 14 institutions in 4 countries.
Kezhi YanRosalind and Morris Goodman Cancer Research Center, McGill University, Montreal, Quebec H3A 1A3, Canada.ORCID 0000-0002-2964-0963
Justine RousseauDepartment of Pediatrics, Sainte-Justine Hospital, University of Montreal, Quebec H3T 1C5, Canada.
Keren MacholDepartment of Molecular and Human Genetics, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA.ORCID 0000-0003-0356-6889
Laura A CrossCenter for Pediatric Genomic Medicine and Department of Clinical Genetics, Children's Mercy Hospital, Kansas City, MO 64108, USA.
Katherine E AgreDepartment of Clinical Genomics, Mayo Clinic, Rochester, MN 55905, USA.
Cynthia Forster GibsonTrillium Health Partners, Credit Valley Hospital, Genetics Program, 2200 Eglinton Ave. W, Mississauga, Ontario L5M 2N1, Canada.
Anne GoverdeDepartment of Clinical Genetics, Erasmus MC, University Medical Center, Rotterdam, Netherlands.ORCID 0000-0002-3238-4411
Kendra L EnglemanCenter for Pediatric Genomic Medicine and Department of Clinical Genetics, Children's Mercy Hospital, Kansas City, MO 64108, USA.
Hannah VerdinCenter for Medical Genetics, Ghent University and Ghent University Hospital, C. Heymanslaan 10, B-9000 Ghent, Belgium.ORCID 0000-0002-0258-1000
Elfride De BaereCenter for Medical Genetics, Ghent University and Ghent University Hospital, C. Heymanslaan 10, B-9000 Ghent, Belgium.
Lorraine PotockiDepartment of Molecular and Human Genetics, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA.
Dihong ZhouCenter for Pediatric Genomic Medicine and Department of Clinical Genetics, Children's Mercy Hospital, Kansas City, MO 64108, USA.
Maxime Cadieux-DionCenter for Pediatric Genomic Medicine and Department of Clinical Genetics, Children's Mercy Hospital, Kansas City, MO 64108, USA.ORCID 0000-0002-3167-9904
Gary A BellusClinical Genetics and Genomic Medicine, Geisinger, 100 N. Academy Ave., Danville, PA 17822, USA.
Monisa D WagnerAutism and Developmental Medicine Institute, Geisinger, 120 Hamm Dr., Lewisburg, PA 17837, USA.
Rebecca J HaleDepartment of Clinical Genomics, Mayo Clinic, Rochester, MN 55905, USA.
Natacha EsberKAT6A Foundation, 3 Louise Dr., West Nyack, NY 10994, USA.ORCID 0000-0002-2004-1083
Alan F RileyTexas Children's Hospital, 6651 Main Street Legacy Tower, 21st Floor Houston, TX 77030, USA.ORCID 0000-0003-0114-6928
Benjamin D SolomonGeneDx, 207 Perry Parkway, Gaithersburg, MD 20877, USA.
Megan T ChoGeneDx, 207 Perry Parkway, Gaithersburg, MD 20877, USA.
Kirsty McWalterGeneDx, 207 Perry Parkway, Gaithersburg, MD 20877, USA.ORCID 0000-0002-1654-9036
Roy EyalKaiser Oakland Medical Center 3600 Broadway, Oakland, CA 94611, USA.ORCID 0000-0002-4589-9406
Meagan K HainlenCenter for Pediatric Genomic Medicine and Department of Clinical Genetics, Children's Mercy Hospital, Kansas City, MO 64108, USA.
Bryce A MendelsohnKaiser Oakland Medical Center 3600 Broadway, Oakland, CA 94611, USA.ORCID 0000-0001-8174-5116
Hillary M PorterDepartment of Genetics and Metabolism, Rare Disease Institute, Children's National Hospital, 111 Michigan Avenue NW, Washington, DC 20010, USA.
Brendan C LanpherDepartment of Clinical Genomics, Mayo Clinic, Rochester, MN 55905, USA.
Andrea M LewisDepartment of Molecular and Human Genetics, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA.
Juliann SavattAutism and Developmental Medicine Institute, Geisinger, 120 Hamm Dr., Lewisburg, PA 17837, USA.
Isabelle ThiffaultCenter for Pediatric Genomic Medicine and Department of Clinical Genetics, Children's Mercy Hospital, Kansas City, MO 64108, USA.ORCID 0000-0001-7987-6731
Bert CallewaertCenter for Medical Genetics, Ghent University and Ghent University Hospital, C. Heymanslaan 10, B-9000 Ghent, Belgium.ORCID 0000-0002-9743-4205
Philippe M CampeauDepartment of Pediatrics, Sainte-Justine Hospital, University of Montreal, Quebec H3T 1C5, Canada.ORCID 0000-0001-9713-7107
Xiang-Jiao YangRosalind and Morris Goodman Cancer Research Center, McGill University, Montreal, Quebec H3A 1A3, Canada.ORCID 0000-0003-0598-120X
Children's Mercy Hospital · USBaylor College of Medicine · USGhent University Hospital · BEMayo Clinic in Florida · USAutism & Developmental Medicine Institute · USCentre Hospitalier Universitaire Sainte-Justine · CAKaiser Permanente Oakland Medical Center · USChildren's National · USCredit Valley Hospital · CAErasmus MC · NLGeisinger Medical Center · USMcGill University · CAMcGill University Health Centre · CATexas Children's Hospital · US
Funding
No grant is acknowledged in the PubMed record.
Abstract
Lysine acetyltransferase 6A (KAT6A) and its paralog KAT6B form stoichiometric complexes with bromodomain- and PHD finger-containing protein 1 (BRPF1) for acetylation of histone H3 at lysine 23 (H3K23). We report that these complexes also catalyze H3K23 propionylation in vitro and in vivo. Immunofluorescence microscopy and ATAC-See revealed the association of this modification with active chromatin.
Indexed as
AcetylationAdaptor Proteins, Signal TransducingAmino Acid SequenceAnimalsBrainBromodomain Containing ProteinsCell LineDisease SusceptibilityDNA-Binding ProteinsDNA Mutational AnalysisGenetic Predisposition to DiseaseHistone AcetyltransferasesHistonesHumansMagnetic Resonance ImagingMiceAdaptor Proteins, Signal TransducingBromodomain Containing ProteinsBRPF1 protein, humanDNA-Binding ProteinsHistone AcetyltransferasesHistonesMultiprotein Complexes
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.