Evidence map›Paper›PMID 32010722›Full record

ArticleERJ open research2020

Skeletal muscle oxygenation and regional blood volume during incremental limb loading in interstitial lung disease.

Lisa Wickerson, Sunita Mathur, Dina Brooks, L V Bonetti, Lianne G Singer, John Granton, W Darlene Reid

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ERJ open research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06769386 (Investigation of Respiratory Muscle Strength, Respiratory Muscle Endurance and Muscle Oxygenation in Patients With Rheumatoid Arthritis), which is not on this map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.4field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06769386 recruitingnot on this mapstarted 2025, after this paper: background citation

Investigation of Respiratory Muscle Strength, Respiratory Muscle Endurance and Muscle Oxygenation in Patients With Rheumatoid Arthritis

TypeobservationalSponsorKirsehir Ahi Evran UniversitesiRan2025 to 2027Enrolled68ConditionsRheumatoid Arthritis
3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 14 citations in OpenAlex.

  1. Trial
  2. Trial
  3. Article
  4. Review
  5. Exercise-induced muscle oxygenation changes in fibrosing interstitial lung diseases: A near-infrared spectroscopy study.Sarcoidosis, vasculitis, and diffuse lung diseases : official journal of WASOG · 2025
    Article
  6. Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 2 countries.

Lisa WickersonToronto Lung Transplant Program, University Health Network, Toronto, ON, Canada.
Sunita MathurDept of Physical Therapy, University of Toronto, Toronto, ON, Canada.
Dina BrooksDept of Physical Therapy, University of Toronto, Toronto, ON, Canada.
L V BonettiRehabilitation Sciences Institute, University of Toronto, Toronto, ON, Canada.
Lianne G SingerToronto Lung Transplant Program, University Health Network, Toronto, ON, Canada.
John GrantonToronto Lung Transplant Program, University Health Network, Toronto, ON, Canada.
W Darlene ReidDept of Physical Therapy, University of Toronto, Toronto, ON, Canada.
Toronto Rehabilitation Institute · CAUniversity of Toronto · CAUniversidade de Caxias do Sul · BRUniversity Health Network · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionIndividuals with interstitial lung disease (ILD) exhibit reduced exercise capacity and exertional hypoxaemia. The role of peripheral (muscle) limitation to exercise tolerance in ILD is not well studied to date.

methodsA prospective cross-sectional study examined skeletal muscle oxygen saturation (

resultsThirteen people who were dependent on oxygen, candidates for lung transplant and with severe ILD (forced vital capacity (FVC) 59±20% predicted), 10 people who were not oxygen dependent with mild ILD (FVC 81±17% predicted) and 13 healthy people (FVC 101±14% predicted) were included. Total haemoglobin, a marker of regional blood volume, was lower at task failure in the knee extensors in participants with severe ILD compared to healthy participants (p=0.05). At task failure for both knee-extensor loading and elbow-flexor loading,

conclusionsOverall, people with severe ILD had lower levels of total work and experienced less increase in blood volume in the knee extensors after knee-extensor loading compared to healthy people. Peripheral muscle dysfunction in severe ILD may have contributed to muscle deoxygenation at lower workloads.

Identifiers

PMID32010722
PMCPMC6983499
OpenAlexW3004011124

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.