Evidence map›Paper›PMID 32010589›Full record

ReviewTranslational lung cancer research2019

Targeting BRAF mutations in non-small cell lung cancer.

Connor Gerard O'Leary, Vladamir Andelkovic, Rahul Ladwa, Nick Pavlakis, Caicun Zhou, Fred Hirsch, Derek Richard, Kenneth O'Byrne

Open access · diamondAbstract readReview
In one paragraph

Review in Translational lung cancer research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
47citing papers in PubMed, 1 pooled it
3.7field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

47 citing papers in PubMed, 1 synthesis or guideline pooled it, 105 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Article
  5. Review
  6. Review
  7. Liquid biopsy in lung cancer.Breathe (Sheffield, England) · 2025
    Review
  8. Nanomedicine Innovations for Lung Cancer Diagnosis and Therapy.ACS applied materials & interfaces · 2025
    Review
  9. Article
  10. Review
  11. Article
  12. Article
  13. Article
  14. Article
  15. Review
  16. Review
  17. Article
  18. Review
  19. Modern therapies of nonsmall cell lung cancer.Journal of applied genetics · 2023
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 3 countries.

Connor Gerard O'LearyPrincess Alexandra Hospital, Brisbane, Australia.
Vladamir AndelkovicPrincess Alexandra Hospital, Brisbane, Australia.
Rahul LadwaPrincess Alexandra Hospital, Brisbane, Australia.
Nick PavlakisRoyal North Shore Hospital, Sydney, Australia.
Caicun ZhouShanghai Pulmonary Hospital, Shanghai, China.
Fred HirschMount Sinai Hospital, New York, NY, USA.
Derek RichardTranslational Research Institute, Brisbane, Australia.
Kenneth O'ByrnePrincess Alexandra Hospital, Brisbane, Australia.
Princess Alexandra Hospital · AUTranslational Research Institute · AUMount Sinai Hospital · USRoyal North Shore Hospital · AUShanghai Pulmonary Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The management of non-small cell lung cancer (NSCLC) has changed significantly with the discovery of specific drug targets. These drugs have helped transform patient care and outcomes. BRAF mutated NSCLC is now recognised as a rare form of lung cancer. Data has begun to emerge supporting the use of BRAF/MEK inhibitors that target BRAF

Indexed as

BRAFV600EdabrafenibNon-small cell lung cancer (NSCLC)trametinibvemurafenib

Identifiers

PMID32010589
PMCPMC6976351
OpenAlexW2989605045

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.