ArticleBiomedical optics express2020
Ultrasensitive THz biosensor for PCR-free cDNA detection based on frequency selective surfaces.
Article in Biomedical optics express, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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Who cites it
7 citing papers in PubMed, 41 citations in OpenAlex.
- AI-Based Metamaterial Design.ACS applied materials & interfaces · 2024Review
- Strong coupling of metamaterials with cavity photons: toward non-Hermitian optics.Nanophotonics (Berlin, Germany) · 2024Article
- A CMOS-integrated terahertz near-field sensor based on an ultra-strongly coupled meta-atom.Scientific reports · 2024Article
- High specificity THz metamaterial-based biosensor for label-free transcription factor detection in melanoma diagnostics.Scientific reports · 2023Article
- Multifrequency Investigation of Single- and Double-Stranded DNA with Scalable Metamaterial-Based THz Biosensors.Biosensors · 2022Article
- Terahertz thermal curve analysis for label-free identification of pathogens.Nature communications · 2022Article
- Terahertz Imaging and Spectroscopy in Cancer Diagnostics: A Technical Review.BME frontiers · 2020Review
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
THz technologies are a powerful tool for label-free detection of biomolecules. However, significant reduction of the lower detection limit is required to apply THz-sensors in biomedical diagnosis. This paper reports an ultrasensitive THz-biosensor based on asymmetric double split ring resonators (aDSRR) for the direct label- and PCR-free detection of DNA at physiologically relevant concentrations. We introduce selective functionalization and localized electric field concentration to enhance aDSRR sensitivity and specificity. The sensor characteristics are demonstrated using the human tumor marker MIA in cDNA samples produced from total RNA without PCR-amplification. Measurements of DNA samples with concentrations as low as 1.55 × 10
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Registered trials
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