Evidence map›Paper›PMID 32010434›Full record

ReviewTherapeutic advances in hematology2020

Insights into the role of intestinal microbiota in hematopoietic stem-cell transplantation.

Daniele Zama, Gianluca Bossù, Davide Leardini, Edoardo Muratore, Elena Biagi, Arcangelo Prete, Andrea Pession, Riccardo Masetti

Open access · goldAbstract readReview
In one paragraph

Review in Therapeutic advances in hematology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
3.0field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 44 citations in OpenAlex.

  1. Article
  2. Diseases (Basel, Switzerland) · 2024
    Review
  3. Review
  4. A review for non-antibiotic treatment ofFrontiers in microbiology · 2024
    Review
  5. Article
  6. Article
  7. Article
  8. Review
  9. Integrative Hematology: State of the Art.International journal of molecular sciences · 2023
    Review
  10. Article
  11. Article
  12. Review
  13. Review
  14. Article
  15. Article
  16. Review
  17. Review
  18. Review
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Daniele ZamaPediatric Oncology and Hematology Unit 'Lalla Seràgnoli,' Sant'Orsola-Malpighi Hospital, University of Bologna, Via Massarenti 11, Bologna, 40137, Italy.ORCID https://orcid.org/0000-0002-9895-5942
Gianluca BossùDepartment of Pediatrics, 'Lalla Seràgnoli,' Hematology-Oncology Unit, University of Bologna, Italy.
Davide LeardiniDepartment of Pediatrics, 'Lalla Seràgnoli,' Hematology-Oncology Unit, University of Bologna, Italy.
Edoardo MuratoreDepartment of Pediatrics, 'Lalla Seràgnoli,' Hematology-Oncology Unit, University of Bologna, Italy.
Elena BiagiDepartment of Pharmacy and Biotechnology, University of Bologna, Bologna, Italy.
Arcangelo PreteDepartment of Pediatrics, 'Lalla Seràgnoli,' Hematology-Oncology Unit, University of Bologna, Italy.
Andrea PessionDepartment of Pediatrics, 'Lalla Seràgnoli,' Hematology-Oncology Unit, University of Bologna, Italy.
Riccardo MasettiDepartment of Pediatrics, 'Lalla Seràgnoli,' Hematology-Oncology Unit, University of Bologna, Italy.
University of Bologna · ITIRCCS Azienda Ospedliero-Universitaria di Bologna Policlinico di Sant'Orsola · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The gut microbiota (GM) is able to modulate the human immune system. The development of novel investigation methods has provided better characterization of the GM, increasing our knowledge of the role of GM in the context of hematopoietic stem-cell transplantation (HSCT). In particular, the GM influences the development of the major complications seen after HSCT, having an impact on overall survival. In fact, this evidence highlights the possible therapeutic implications of modulation of the GM during HSCT. Insights into the complex mechanisms and functions of the GM are essential for the rational design of these therapeutics. To date, preemptive and curative approaches have been tested. The current state of understanding of the impact of the GM on HSCT, and therapies targeting the GM balance is reviewed herein.

Indexed as

fecal microbiota transplantationgraft-vs-host-diseasegut microbiotahematopoietic stem-cell transplantationnutritionpostbioticprebiotic

Identifiers

PMID32010434
PMCPMC6974760
OpenAlexW3002031918

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.