Evidence map›Paper›PMID 32010404›Full record

ArticleOpen access Macedonian journal of medical sciences2019

The Prognostic Significance of Phosphatase and Tensin Homolog Loss in Breast Cancer.

Indri Windarti, Wirsma Arif Harahap, Ricvan Dana Nindrea, Eti Yerizel, Primariadewi Rustamadji

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PubMed Full text at PMC Publisher
In one paragraph

Article in Open access Macedonian journal of medical sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Indri WindartiFaculty of Medicine, Andalas University, Padang, Indonesia.
Wirsma Arif HarahapDepartment of Surgical, Oncology Division, Faculty of Medicine, Andalas University, Dr M Djamil General Hospital, Padang, Indonesia.
Ricvan Dana NindreaDepartment of Public Health and Community Medicine, Faculty of Medicine, Andalas University, Padang, Indonesia.
Eti YerizelDepartment of Biomolecular and Biochemistry, Faculty of Medicine, Andalas University, Padang, Indonesia.
Primariadewi RustamadjiDepartment of Anatomical Pathology, Faculty of Medicine, Indonesia University, Cipto Mangunkusumo General Hospital, Jakarta, Indonesia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimThis study aims to determine the prognostic significance of phosphatase and tensin homolog (PTEN) loss in breast cancer.

methodsWe conducted a meta-analysis study. Sample of this study were research articles that evaluated PTEN loss and prognosis in breast cancer patients. We searched for relevant studies published in PubMed and Proquest from January 2010 to July 2018. We reviewed studies that examined the association between immunohistochemical expression of PTEN and breast cancer prognosis using meta-analysis methods. Pooled risk ratios (RR) were calculated using fixed and random-effect models. Data were processed using Review Manager 5.3 (RevMan 5.3).

resultsThere were 7 studies conducted a systematic review then continued to evaluate the association of PTEN loss and breast cancer prognosis by meta-analysis. There was a significant association of PTEN loss with poor prognosis of breast cancer (RR = 0.76 [95% CI 0.59-0.98 p <0.07), and there was not any significant publication bias for studies included.

conclusionThis study confirmed PTEN loss is an important independent factor for breast cancer prognosis.

Indexed as

Breast cancerImmunohistochemicalPrognosisPTEN

Identifiers

PMID32010404
PMCPMC6986515

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.